PMID: 2126478Sep 10, 1990Paper

Induction of Fos in glia-like cells after focal brain injury but not during wallerian degeneration

Brain Research
M DragunowR L Faull

Abstract

Focal brain injury or perforant-path transections respectively led to an increase in the number of glial-fibrillary acidic protein (GFAP)-immunopositive astrocytes around the focal wound or in the terminal fields of the perforant path in the dentate molecular layer. This GFAP accumulation occurred 48-72 h after focal brain injury or perforant-path transection (wallerian degeneration). Focal brain injury also led to an accumulation of c-fos protein (Fos) in glial cells, ependyma and cells in the pia mater of the brain within 6 h of injury and this effect dissipated within 72 h. However, perforant-path lesions were not associated with accumulation of Fos in glial cells in the dentate molecular layer suggesting that c-fos induction in glial cells after injury is not necessary for GFAP accumulation. Induction of Fos in glia, ependyma and pia after focal brain injury may be associated with proliferation of these cells after injury.

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Citations

May 15, 1996·Journal of Neuroscience Research·M Araujo, F Wandosell
Jul 1, 1992·Journal of Neuroscience Research·N R BhatM S Kindy
Jul 1, 1995·Brain Research. Brain Research Reviews·M Dragunow, K Preston
Sep 1, 1992·Brain Research. Molecular Brain Research·M Dragunow
May 1, 1992·Brain Research. Molecular Brain Research·P HughesM Dragunow
May 26, 1995·Neuroscience Letters·M Dragunow
Apr 1, 1993·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·M Dragunow, P Hughes
Sep 1, 1995·Trends in Pharmacological Sciences·K R PennypackerM K McMillian
Oct 31, 1998·Brain Research. Molecular Brain Research·M WaltonM Dragunow
Oct 1, 1996·Progress in Neurobiology·D G Herrera, H A Robertson
Dec 21, 2000·Neuropathology and Applied Neurobiology·M GiannakopoulouF Stylianopoulou
Oct 9, 2002·Neuropathology and Applied Neurobiology·X YeR I Carp
Aug 1, 1992·Neuropathology and Applied Neurobiology·P Collins, D A Goulding
Jan 1, 1992·The European Journal of Neuroscience·Manuel A. Castro-AlamancosJosé Borrell
Mar 2, 2010·Expert Review of Neurotherapeutics·Anna P AndreouPeter J Goadsby

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