Induction of Fos-protein in the forebrain and disruption of sensorimotor gating following N-methyl-D-aspartate infusion into the ventral hippocampus of the rat

Neuroscience
A KlarnerH U Schnitzler

Abstract

Several neuropsychiatric disorders, including schizophrenia, are characterized by sensorimotor gating deficits. Prepulse inhibition of the acoustic startle response is an operational measure assessing sensorimotor gating and has been found to be reduced in schizophrenic patients. Much attention has therefore been paid to the neuronal mechanisms underlying the disruption of prepulse inhibition. The activity of limbic forebrain structures such as the septohippocampal system, the prefrontal cortex, and the nucleus accumbens has been the main focus of recent research into the regulation of prepulse inhibition in rats. We here provide a functional anatomical picture of forebrain structures probably involved in the regulation of prepulse inhibition. Stimulation of the ventral hippocampus with a subconvulsive dose of N-methyl-D-aspartate caused a significant and long-lasting disruption of prepulse inhibition. Immunostaining of the c-Fos protein revealed a characteristic pattern of neuronal activity in various forebrain areas, including the nucleus accumbens and different frontal cortical areas after hippocampal stimulation. Based on the present findings, we conclude that the overactivity within a network of cortico-limbic forebrain st...Continue Reading

References

Dec 1, 1992·Pharmacology, Biochemistry, and Behavior·S B CaineN R Swerdlow
Sep 4, 1991·European Journal of Pharmacology·R S Mansbach
Jan 1, 1988·Psychopharmacology·R S MansbachD L Braff
Aug 1, 1985·Archives of General Psychiatry·B BogertsR Schönfeldt-Bausch
Dec 1, 1980·Journal of Neuroscience Methods·G PaxinosP C Emson
Mar 1, 1995·Neurodegeneration : a Journal for Neurodegenerative Disorders, Neuroprotection, and Neuroregeneration·P J Harrison
Mar 1, 1993·Pharmacology, Biochemistry, and Behavior·N R Swerdlow, M A Geyer
Dec 1, 1996·Progress in Neurobiology·W Löscher, U Ebert
Feb 25, 1998·Behavioural Brain Research·M Koch, H U Schnitzler
Aug 26, 1998·Biological Psychiatry·M Koch, U Ebert

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Citations

Feb 13, 2001·Pharmacology, Biochemistry, and Behavior·T BastI M White
Sep 6, 2002·Pharmacology, Biochemistry, and Behavior·W-N ZhangJ Feldon
Dec 28, 2000·Behavioural Brain Research·J LehmannJ Feldon
Sep 10, 2003·Progress in Neurobiology·Tobias Bast, Joram Feldon
Aug 27, 1999·Progress in Neurobiology·M Koch
Jan 8, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·François LaplanteRémi Quirion
Feb 14, 2006·Psychiatry and Clinical Neurosciences·Akinori UekiYoshio Morita
Jul 23, 1999·Annals of the New York Academy of Sciences·N R SwerdlowM A Geyer
Mar 26, 2003·The European Journal of Neuroscience·Hong LiKazutada Watanabe
Jun 24, 2014·Progress in Neuro-psychopharmacology & Biological Psychiatry·Hyun WooJong Hoon Ryu
May 12, 2012·Neuropharmacology·Dean T AchesonVictoria B Risbrough
May 3, 2014·The International Journal of Neuropsychopharmacology·Kathryn M Gill, Anthony A Grace
Aug 19, 2007·The Journal of Physiology·Sreedharan SajikumarJulietta U Frey

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