Induction of Fos protein in the rat hypothalamus elicited by insulin-induced hypoglycemia

Neuroscience Research
M NiimiK Kawanishi

Abstract

To evaluate the responses to insulin-induced hypoglycemia of neurons in vivo, we studied Fos protein induction in the brain by means of immunohistochemistry. The induction of Fos protein was maximum after the first injection of insulin for 3 h. This induction was found in the parvocellular division of paraventricular nucleus (PVN), the periventricular, dorsomedial and arcuate nuclei and the lateral hypothalamic area of the hypothalamus. These findings show the activation of specific subsets of neurons in areas of the hypothalamus following hypoglycemic stimulation.

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Citations

Aug 30, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Salwa Al-NooriDianne P Figlewicz
Jul 15, 2015·Trends in Endocrinology and Metabolism : TEM·Laura SteinbuschBernard Thorens
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