Induction of G2/M cell cycle arrest and apoptosis by a benz[f]indole-4,9-dione analog in cultured human lung (A549) cancer cells

Bioorganic & Medicinal Chemistry Letters
Eun-Jin LeeSang Kook Lee

Abstract

A synthetic benz[f]indole-4,9-dione analog, 2-amino-3-ethoxycarbonyl-N-methylbenz[f]indole-4,9-dione (SME-6), showed a potent growth inhibition of a panel of human cancer cell lines. The mechanism of action study revealed that the growth inhibitory effect of SME-6 was highly related to the induction of G2/M cell cycle arrest and apoptosis in human lung cancer cells (A549). These data may provide new information for understanding the mechanisms by benz[f]indole-4,9-diones-mediated antitumor activity.

References

Mar 10, 1995·Science·H Steller
Aug 1, 1993·Trends in Biochemical Sciences·M K Collins, A Lopez Rivas

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Citations

Jun 14, 2005·Bioorganic & Medicinal Chemistry Letters·Vishnu K TandonPraveen K Shukla
Jan 24, 2012·Journal of Asian Natural Products Research·Alireza NematollahiChristophe Wiart

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