Induction of GDNF mRNA expression by melatonin in rat C6 glioma cells

Neuroreport
Kristen J Armstrong, Lennard P Niles

Abstract

In order to determine the physiological effect of melatonin on glial cell line-derived neurotrophic factor (GDNF), which is reportedly up-regulated by high doses of this hormone, concentration-dependent studies were carried out in cultured cells. RT-PCR studies indicated that, in addition to GDNF, rat C6 glioma cells express both of the G protein-coupled melatonin receptor subtypes, MT1 and MT2. When C6 cells were treated with physiological (0.05-1 nM) or higher (10 and 100 nM) concentrations of melatonin for 24 h, a significant induction of relative GDNF mRNA levels (n = 4) was detected by semi-quantitative RT-PCR. These findings suggest that induction of GDNF is involved in physiological neuroprotection by melatonin. Given the potency of GDNF in maintaining nigrostriatal dopaminergic integrity, understanding the mechanisms of its induction by melatonin could provide novel therapies for Parkinson's disease.

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Citations

Oct 4, 2007·Cellular and Molecular Neurobiology·Xiangying KongPingping Zuo
Apr 3, 2009·The Journal of Physiological Sciences : JPS·Hirotaka IshiiYasuo Sakuma
Oct 1, 2008·Progress in Neurobiology·Ana SaavedraEmília P Duarte
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Sep 24, 2011·Progress in Neuro-psychopharmacology & Biological Psychiatry·Inmaculada TassetIsaac Túnez
Nov 20, 2013·Neurobiology of Aging·Oliver T Phillipson
Jan 17, 2012·The International Journal of Neuropsychopharmacology·Lennard P NilesYi Pan
Jul 10, 2008·The International Journal of Neuropsychopharmacology·Xuefei WuJau-Shyong Hong
Oct 28, 2009·Progress in Neurobiology·Kailash Manda, Russel J Reiter
Nov 11, 2016·Oxidative Medicine and Cellular Longevity·Josiel Mileno MackRui Daniel Prediger
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Oct 7, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Dao-Yao He, Dorit Ron
Oct 2, 2020·International Journal of Molecular Sciences·Fang LuoXin Wang

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