Induction of genetic duplications and frameshift mutations in Salmonella typhimurium by acridines and acridine mustards: dependence on covalent binding of the mutagen to DNA.

Molecular & General Genetics : MGG
G R HoffmannL A Parente

Abstract

The aroC321 allele permits positive selection for the detection of a large genetic duplication that arises in the Salmonella typhimurium chromosome by homologous recombination. Strains that contain both aroC321 and the hisC3076 allele were constructed so that the induction of genetic duplications and frameshift mutations in a run of GC base pairs could be studied simultaneously by selecting for tryptophan and histidine prototrophy, respectively. Using these strains, we examined the ability of 9-aminoacridine, quinacrine, four acridine mustards (ICR-170, ICR-191, ICR-372, and quinacrine mustard) and the nitroacridine Entozon to induce genetic duplications and frameshift mutations. Although all these compounds induce reversion of hisC3076, only the four mustards and Entozon are effective as inducers of genetic duplications under identical treatment conditions. The induction of genetic duplications by acridine mustards, like the toxic and mutagenic effects of these compounds, is enhanced by a deficiency for excision repair caused by a deletion through the uvr B gene. The ineffectiveness of 9-aminoacridine and quinacrine in the test for genetic duplications indicates that simple intercalation is sufficient for the mutagenic effect ...Continue Reading

References

Jan 1, 1977·Annual Review of Microbiology·R P Anderson, J R Roth
Dec 1, 1979·Mutation Research·A Nasim, T Brychcy
Sep 1, 1976·Mutation Research·G E Murray, P F Smith-Keary
Dec 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·J McCannB N Ames
Jan 1, 1986·Annual Review of Genetics·A G Knudson
Jan 1, 1987·Environmental and Molecular Mutagenesis·G R HoffmannD H Wroblewski
Jul 1, 1986·Mutation Research·W K CaveneeM F Hansen
Jan 1, 1988·Environmental and Molecular Mutagenesis·G R HoffmannC S Freemer
Feb 1, 1988·Mutation Research·D M DeMariniM M Moore
Apr 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·R T SchimkeR N Johnston
Jan 1, 1986·Environmental Mutagenesis·P E HartmanD E Levin
Aug 1, 1986·Molecular & General Genetics : MGG·M L Pall, B J Hunter
Jan 16, 1987·Science·J M Bishop
Nov 1, 1985·Mutation Research·M L Pall, B J Hunter
Jun 1, 1985·Journal of Bacteriology·A M Albertini, A Galizzi
Dec 31, 1973·Molecular & General Genetics : MGG·C W Hill, G Combriato
Jan 1, 1972·Molecular & General Genetics : MGG·H Schmieger
Jan 1, 1984·Molecular & General Genetics : MGG·T R Skopek, F Hutchinson
Sep 1, 1983·Microbiological Reviews·K E Sanderson, J R Roth
May 1, 1984·Cell·T D TlstyJ H Miller
May 1, 1983·Mutation Research·D M Maron, B N Ames
May 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·C Luisi-DeLucaW D Taylor
May 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·P Anderson, J Roth
Aug 1, 1980·Mutation Research·B R BrownL W Yielding
Nov 25, 1981·Journal of Molecular Biology·M P Calos, J H Miller

❮ Previous
Next ❯

Citations

Dec 1, 1992·Mutation Research·G R Hoffmann
Apr 1, 1991·Biochimie·J D Heath, G M Weinstock
Jun 1, 1993·Molecular Microbiology·J M Martínez-SalazarG Soberón-Chavez
Jan 29, 2003·Environmental and Molecular Mutagenesis·Sophie MeintièresDaniel Marzin
Feb 28, 2002·Genome Biology·Fyodor A KondrashovEugene V Koonin
Aug 12, 2010·PLoS Computational Biology·Masaki E Tsuda, Masakado Kawata
Sep 27, 2003·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·M GuhaMajumdarB B Sears
Jan 1, 1994·Environmental and Molecular Mutagenesis·G R Hoffmann
Sep 1, 1991·Mutation Research·L R Ferguson, W A Denny

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.