Induction of glandular stomach cancers in Helicobacter pylori-sensitive Mongolian gerbils treated with N-methyl-N-nitrosourea and N-methyl-N'-nitro-N-nitrosoguanidine in drinking water

Japanese Journal of Cancer Research : Gann
Masae TatematsuT Ikeno

Abstract

An animal model of stomach carcinogenesis was established using Mongolian gerbils with N-methyl-N-nitrosourea (MNU) and N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) as the carcinogens. In addition, the sensitivity of these gerbils to Helicobacter pylori (H. pylori) was confirmed. One hundred and sixty specific pathogen-free male MGS/Sea animals, 7 weeks old, were treated with MNU in the drinking water (30 ppm for alternate weeks to give 10 weeks exposure, or 10 ppm or 3 ppm for 20 weeks continuous exposure), or given MNNG in the drinking water at 400 ppm or 200 ppm for 20 weeks, or orally inoculated with ATCC43504 H. pylori (1.7 x 10(8) CFUs/animal). Adenocarcinomas in the glandular stomach were found in 2 out of 12 effective animals (2/ 12) treated with 30 ppm MNU at week 20, although all were dead or moribund by week 30 due to MNU toxicity. At week 50, the incidences of gastric adenocarcinomas in groups treated with 10 ppm MNU, 3 ppm MNU, 400 ppm MNNG, and 200 ppm MNNG were 2/21 (9.5%), 1/23 (4.3%), 7/ 11 (63.6%), and 1/10 (10.0%). The lesions were generally well differentiated, although poorly differentiated adenocarcinoma was also found in a single gerbil in each of the 10 ppm MNU and 400 ppm MNNG groups. In control animals ...Continue Reading

References

Sep 1, 1992·Japanese Journal of Cancer Research : Gann·M TatematsuN Ito
Oct 17, 1991·The New England Journal of Medicine·J ParsonnetR K Sibley
Oct 17, 1991·The New England Journal of Medicine·A NomuraM J Blaser
Aug 1, 1990·Infection and Immunity·M J RadinJ Fox
Dec 1, 1993·Japanese Journal of Cancer Research : Gann·M TatematsuH Nakanishi
Sep 4, 1996·International Journal of Cancer. Journal International Du Cancer·P M WebbR K Ross
Sep 1, 1955·British Journal of Cancer·B C MORSON

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Citations

Nov 1, 2012·Seminars in Immunopathology·Tetsuya TsukamotoMasae Tatematsu
Nov 19, 2003·Biochemical and Biophysical Research Communications·Yasuhiko KitadaiKazuaki Chayama
Mar 1, 2012·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·Lin ZhangDan Li
Mar 29, 2014·Current Infectious Disease Reports·Tetsuya Tsukamoto, Masae Tatematsu
Feb 13, 2003·Mutation Research·Naotaka ToriiKazumasa Miki
Dec 24, 2004·Journal of Cancer Research and Clinical Oncology·Masami SuganumaHirota Fujiki
May 13, 2009·Cancer Science·Nao YoshizawaMichio Kaminishi
Jul 27, 2007·Toxicologic Pathology·Tetsuya TsukamotoMasae Tatematsu
Apr 20, 2017·International Journal of Molecular Sciences·Yusuke KandaFutoshi Okada
Apr 15, 2004·Alimentary Pharmacology & Therapeutics·D M Pritchard, S M C Przemeck
Nov 16, 2007·Laboratory Investigation; a Journal of Technical Methods and Pathology·Nao YoshizawaMichio Kaminishi
Aug 5, 2017·International Journal of Molecular Sciences·Tetsuya TsukamotoXueyuan Cao
Jan 22, 2004·International Journal of Cancer. Journal International Du Cancer·Hiroshi OhataMasao Ichinose
Feb 6, 2017·Disease Models & Mechanisms·Michael D BurkittD Mark Pritchard
Jul 26, 2014·Journal of Gastric Cancer·Sungsook YuKi Taek Nam
Jan 24, 2007·Journal of Gastroenterology·Masae TatematsuTakeshi Toyoda
Dec 22, 2005·International Journal of Clinical Oncology·Hitoshi Katai, Takeshi Sano
Oct 8, 2005·Oncology·Michio Kaminishi
Dec 11, 1999·Carcinogenesis·C T Stadtländer, J W Waterbor
Jun 5, 2003·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Xin WangTorkel Wadström
Oct 30, 2001·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Y KetoS Okabe
Nov 13, 2013·Cancers·Yoku HayakawaTimothy C Wang
May 2, 2002·Journal of Gastroenterology and Hepatology·Sang-Uk HanMyung-Wook Kim
Dec 13, 2005·Scandinavian Journal of Gastroenterology·Anders ElfvinMichael Vieth
Jan 27, 2006·World Journal of Gastroenterology : WJG·Masaaki KodamaToshio Fujioka
Jun 6, 2002·Alimentary Pharmacology & Therapeutics·R M Genta

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