PMID: 42916Dec 1, 1979Paper

Induction of glutamine synthetase in embryonic neural retina: localization in Müller fibers and dependence on cell interactions

Proceedings of the National Academy of Sciences of the United States of America
P Linser, A A Moscona

Abstract

The cellular localization of glutamine synthetase [GSase; L-glutamate:ammonia ligase(ADP)-forming), EC 6.3.1.2] induced by cortisol in the neural retina of chicken embryos was investigated by immunostaining with GSase-specific antiserum and indirect immunofluorescence. In organ cultures of retina tissue, and in the retina in vivo, hormone-induced GSase was found to be confined only to the Müller fibers (retinoglia). Also, in mature chicken retina, which contains a very high level of GSase, the enzyme was detected solely in Müller fibers. In short-term monolayer cultures of dispersed embryonic retina cells, there was no GSase induction and no immunodetectable increase in enzyme level. However, when the dispersed cells were reaggregated and they restituted retinotypic cell associations, GSase could be induced and it was localized in Müller fibers. The results suggest that, in addition to the hormonal stimulus, contact-dependent interactions between Müller glia cells and retina neurons are involved in the mechanism of GSase induction in the retina.

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Citations

May 23, 2000·The Anatomical Record·M M Jablonski, C S Ervin
Aug 24, 1999·Journal of Neurobiology·L VardimonL Shiftan
Apr 1, 1993·Developmental Dynamics : an Official Publication of the American Association of Anatomists·J M Fadool, P J Linser
Apr 1, 1993·Developmental Dynamics : an Official Publication of the American Association of Anatomists·L VardimonL E Fox
Oct 1, 1995·Glia·K R HuxlinB Dreher
Jan 29, 2002·Journal of Neuroscience Research·Amira WohabrebbiMonica M Jablonski
Nov 1, 1990·Journal of Neuroscience Research·U VielkindM C Bohn
Apr 1, 1993·Cell and Tissue Research·R GábrielC Straznicky
Jan 1, 1984·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·R H Rhodes
Nov 1, 1990·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·M MoyerJ B Sheffield
Apr 1, 1989·Developmental Biology·A ThrelkeldA T Hewitt
Dec 1, 1988·Experimental Eye Research·G P LewisS K Fisher
Jan 1, 1981·Cell Differentiation·A A Moscona, L Degenstein
Jun 1, 1985·Cell Differentiation·A D Saad, A A Moscona
Mar 1, 1987·Cell Differentiation·P J Linser, M S Perkins
Jun 1, 1983·Brain Research·D G Puro
Dec 1, 1989·Brain Research. Molecular Brain Research·K M MearowL Vitkovic
Feb 1, 1994·Brain Research. Molecular Brain Research·R GrossmanL Vardimon
May 1, 1994·Neuroscience·D V Pow, S R Robinson
Jan 1, 1995·Brain Research Bulletin·V ShacooriB Rault

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