PMID: 6110468Jan 1, 1981Paper

Induction of glutamine synthetase in embryonic neural retina: its suppression by the gliatoxic agent alpha-aminoadipic acid

Brain Research
P J Linser, A A Moscona

Abstract

Competence for cortisol-mediated induction of glutamine synthetase (GS) is a differentiation marker of embryonic neural retina. Earlier work has indicated that the induction and accumulation of GS is localized in the Müller glia cells. This localization was presently confirmed by the finding that the gliatoxin D,L-alpha-amino-adipic acid (AAA) reduces responsiveness to GS induction by 60--90% due to preferential damage to Müller cells. The tests were performed on organ cultures of retina tissue from chick embryos, and on retina cell aggregates in which there is tissue reconstruction. The presence of GS-inducible Müller cells was monitored by immuno-staining of tissue sections with anti-GS antiserum. Reduction of GS inducibility due to pretreatment with AAA resulted in virtual absence of cells that immunostained for GS. The preferential toxicity of AAA for Müller cells was also demonstrated by cell viability tests; it was further corroborated by the finding that treatment with AAA greatly reduced the level of carbonic anhydrase activity, another enzyme localized predominantly in Müller cells, but did not affect gamma-aminobutyric acid transaminase and choline acetyl transferase, neuronal enzymes. Susceptibility of Müller cells t...Continue Reading

References

Aug 18, 1977·Nature·R E Riepe, M D Norenburg
Sep 1, 1978·The Journal of Cell Biology·P V Sarthy, D M Lam
Dec 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·P Linser, A A Moscona
Jan 1, 1979·Differentiation; Research in Biological Diversity·M Moscona, A A Moscona
Dec 1, 1979·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M S GhandourG Gombos
Jun 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·P K Sarkar, A A Moscona
Jun 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·A W Wiens, A A Moscona
Jan 1, 1973·Experimental Eye Research·G L Musser, S Rosen
Sep 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·A A MosconaN Saenz

❮ Previous
Next ❯

Citations

May 1, 1992·Developmental Dynamics : an Official Publication of the American Association of Anatomists·R J BuonoJ Piatigorsky
Dec 1, 1983·Brain Research·V Lemmon, G Rieser
Jul 1, 1984·Brain Research·F GremoA Vernadakis
Dec 1, 1990·Brain Research. Developmental Brain Research·K Akagawa
Feb 1, 1994·Brain Research. Molecular Brain Research·R GrossmanL Vardimon
Jan 1, 1985·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·C A Landa, A A Moscona
Aug 1, 1995·Experimental Eye Research·K A RichJ C Blanks
Nov 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·P Linser, A A Moscona
Dec 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·A A MosconaB M Soh
Dec 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·L VardimonA A Moscona
Feb 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·I Ben-DrorL Vardimon
Apr 1, 1984·Current Eye Research·M C Trachtenberg, D J Packey
May 1, 1989·Journal of Neurochemistry·G TesoriereM R Schiavo
Mar 1, 1989·Journal of Neurochemistry·D GravottaH J Maccioni
Jul 26, 2008·Nature Nanotechnology·Junping ChenJames F McGinnis
Apr 1, 1993·Developmental Dynamics : an Official Publication of the American Association of Anatomists·J M Fadool, P J Linser
Aug 24, 1999·Journal of Neurobiology·L VardimonL Shiftan
Dec 24, 2009·Journal of Neuroscience Research·Weiyong ShenMark C Gillies
Jan 1, 1985·Annals of the New York Academy of Sciences·K I Kivirikko, R Myllylä

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.