Induction of glutathione synthetase by 1,10-phenanthroline

FEBS Letters
Y Sun

Abstract

The differential display (DD) was employed to identify the gene(s) responsible for 1,10-phenanthroline (OP)-induced apoptosis in murine tumor cells (Sun, Y., Bian, J., Wang, Y. and Jacobs, C. (1997) Oncogene 14, 385-393 [1]). An OP-inducible gene was isolated which encodes mouse glutathione synthetase (GSS). The GSS mRNA level began to increase 6 h post OP treatment and remained at a high level thereafter up to 24 h tested. Induction of GSS was found not to be associated with p53 activation. No significant induction of DNA fragmentation was detected in two murine tumor lines upon GSS transfection. This is the first observation indicating that GSS is inducible rather specifically by a metal chelator and that induction of GSS, however, is not sufficient to induce apoptosis. It may merely reflect a cellular response to OP-induced redox disturbance.

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Citations

Feb 23, 2000·Archives of Biochemistry and Biophysics·J ChoiH J Forman
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Jul 29, 2006·Molecular and Cellular Biochemistry·Hongbin HeYi Sun
Dec 18, 2010·Dalton Transactions : an International Journal of Inorganic Chemistry·Andrew KellettMichael Devereux

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis