PMID: 9170417Apr 15, 1997Paper

Induction of granulocyte colony-stimulating factor by acute febrile infection but not by neutropenia in HIV-seropositive individuals

Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association
S MaussH Jablonowski

Abstract

The objective of this study was to assess endogenous granulocyte colony-stimulating factor (G-CSF) serum levels in HIV-seropositive individuals with persistent neutropenia or acute febrile infection. Serum levels of G-CSF were measured by enzyme-linked immunoabsorbent assay. HIV-seropositive subjects (n = 28) with afebrile neutropenia (< 1000 neutrophils/microliter) showed low G-CSF serum levels (i.e., median was below the detection limit) not different from those of healthy volunteers (n = 66) or nonneutropenic HIV-seropositive controls (n = 75). In contrast, patients with acute myeloid leukemia and afebrile neutropenia from chemotherapy (n = 17) demonstrated markedly elevated G-CSF levels (median, 264 pg/ml; p < 0.0001). However, HIV-seropositive patients with pneumonia (n = 17) showed increases of G-CSF serum levels (median, 152 pg/ml; p < 0.0001) similar to HIV-seronegative patients (n = 17) with pneumonia (median, 123 pg/ml; p = 0.97). The results suggest that there may be a contribution of low G-CSF serum levels to persistent neutropenia in HIV-seropositive individuals. Moreover, the different G-CSF serum levels in HIV-seropositive individuals in response to neutropenia or acute febrile inflammation suggest different mech...Continue Reading

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Citations

Aug 7, 1999·Clinical Reviews in Allergy & Immunology·M Peters-Golden, M Coffey
Feb 15, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D R Kuritzkes
Feb 15, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D A MooreB G Gazzard
Mar 7, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·W S Armstrong, P Kazanjian
Dec 3, 2014·The Lancet Infectious Diseases·Michaëla A M HusonTom van der Poll
Apr 3, 2012·Hematology/oncology Clinics of North America·John L Reagan, Jorge J Castillo
Nov 25, 2006·The Lancet Infectious Diseases·Mahdad NoursadeghiRobert F Miller
Oct 30, 1998·The Journal of Laboratory and Clinical Medicine·M Peters-Golden, M Coffey
Oct 22, 2010·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Cynthia FirnhaberThomas B Campbell
Mar 25, 2014·International Reviews of Immunology·Xin ShiPing Zhang
Aug 16, 2000·Baillière's Best Practice & Research. Clinical Haematology·R H Evans, D T Scadden

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