PMID: 9191105Jun 1, 1997Paper

Induction of heat-shock protein (HSP72) in the cingulate and retrosplenial cortex by drugs that antagonize the effects of excitatory amino acids

Brain Research. Molecular Brain Research
J Q LanS H Graham

Abstract

To address the issue of the cytotoxicity of glutamate antagonists, we administered representative agents to rats and used HSP72 immunocytochemistry as a measure of neuronal injury in the brain. The doses studied spanned the reported neuroprotective range for each compound. Some, but not all, glutamate antagonists induce neuronal injury in the brain. The non-competitive NMDA antagonists (MK801 and dextrorphan) demonstrate maximum toxicity. Competitive NMDA antagonists (CGS 19755 and MDL 100,453) may or may not induce neuronal injury depending on the particular compound. The polyamine site (SL 82.0715-10) antagonist does not result in neuronal injury. Cingulate and retrosplenial cortex neurotoxicity is not a ubiquitous feature of neuroprotective agents that block excitotoxcity, but is limited to NMDA antagonists and may depend upon the duration and completeness of the blockade of the NMDA receptor.

References

May 28, 1992·The New England Journal of Medicine·J D RothsteinR W Kuncl
Jul 1, 1991·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·F R SharpK Hisanaga
Sep 1, 1989·Trends in Neurosciences·A M Thomson
Jul 1, 1989·Brain Research. Molecular Brain Research·M F GonzalezF R Sharp
Mar 1, 1995·Stroke; a Journal of Cerebral Circulation·K W Muir, K R Lees
Mar 3, 1994·The New England Journal of Medicine·S A Lipton, P A Rosenberg
Jul 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S S GlazierF A Welsh
Jun 1, 1994·Stroke; a Journal of Cerebral Circulation·Y HasegawaG Metcalf

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