Induction of heme oxygenase-1 expression inhibits platelet-dependent thrombosis

Antioxidants & Redox Signaling
Lin PengWilliam P Fay

Abstract

Heme oxygenase-1 (HO-1) plays a key role in protecting tissue from oxidative stress. Although some studies implicate HO-1 in modulating thrombosis after vascular injury, the impact of HO-1 on the rate of clot formation in vivo is poorly defined. This study examined the potential function of HO-1 in regulating platelet-dependent arterial thrombosis. Platelet-rich thrombi were induced in C57BL/6J mice by applying 10% ferric chloride to the exposed carotid artery. Mean occlusion time of wild-type mice (n = 10) was 14.6 +/- 1.0 min versus 12.9 +/- 0.6 min for HO-1-/- mice (n = 11, p = 0.17). However, after challenge with hemin, mean occlusion time was significantly longer in wild-type mice (16.3 +/- 1.2 min, n = 15) than HO-1-/- mice (12.0 +/- 1.0 min, n = 9; p = 0.021). Hemin administration induced an approximately twofold increase in oxidative stress, measured as plasma thiobarbituric acid reactive substances. Immunohistochemical analysis revealed that hemin induced a robust increase in HO-1 expression within the carotid arterial wall. Ex vivo blood clotting within a collagen-coated perfusion chamber was studied to determine whether the accelerated thrombosis observed in HO-1-/- mice was contributed to by effects on the blood its...Continue Reading

References

Nov 20, 1989·European Journal of Biochemistry·M L Kremer
Feb 14, 1997·The Journal of Biological Chemistry·S F YetM A Perrella
Jun 1, 1997·Cardiovascular Research·G AmbrosioP Golino
Aug 1, 1997·The Journal of Clinical Investigation·C T WagnerA I Schafer
Oct 6, 1997·Proceedings of the National Academy of Sciences of the United States of America·K D Poss, S Tonegawa
Oct 6, 1997·Proceedings of the National Academy of Sciences of the United States of America·K D Poss, S Tonegawa
Dec 5, 1998·The Journal of Biological Chemistry·S A NowellL T Frame
Jan 12, 1999·The Journal of Clinical Investigation·A YachieS Koizumi
Mar 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·S DoréS H Snyder
Apr 20, 1999·The Journal of Clinical Investigation·S F YetM E Lee
Jul 7, 1999·The Journal of Clinical Investigation·H SuzukiT Tanaka
Jul 16, 1999·Vascular Medicine·L D Horwitz, E A Rosenthal
Dec 22, 1999·Proceedings of the Society for Experimental Biology and Medicine·R Galbraith
Mar 10, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·K SatoM P Soares
Jun 1, 2001·Nature Medicine·H J DuckersE G Nabel
Jul 2, 2002·American Journal of Respiratory Cell and Molecular Biology·Danielle Morse, Augustine M K Choi
Jul 20, 2002·Methods in Enzymology·Olaf Herkert, Agnes Görlach
Aug 9, 2002·Biochemical Pharmacology·Cheng-Gang ZouGraham Lloyd Jones
Jun 20, 2003·Journal of Neuroscience Research·Laurel GoldsteinRaymond F Regan
Sep 6, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Shaw-Fang YetMark A Perrella

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Citations

Jul 10, 2004·Antioxidants & Redox Signaling·Agnes Görlach
Aug 24, 2005·Antioxidants & Redox Signaling·Agnes Görlach
Nov 26, 2010·Antioxidants & Redox Signaling·Meng-Ling WuShaw-Fang Yet
Nov 2, 2007·Clinical and Experimental Pharmacology & Physiology·Gaël Y RochefortDaniel Antier
Jul 19, 2011·Pharmacology & Therapeutics·Nicola J Truss, Timothy D Warner
Nov 8, 2008·The American Journal of Pathology·Michal J TraczKarl A Nath
Nov 6, 2008·Journal of Thrombosis and Haemostasis : JTH·J J O'BrienR P Phipps
Apr 2, 2015·European Heart Journal·Laura E FredenburghSusan Cheng
Dec 15, 2015·Frontiers in Cardiovascular Medicine·Aleksandra Piechota-PolanczykChristine Brostjan
May 23, 2012·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Xiao-li LiJun-hong Zhang
Nov 24, 2007·Pharmacogenomics·Raoul FrijtersJan Polman
Jun 30, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Randal J WestrickDaniel T Eitzman
Nov 15, 2006·Circulation·Roland Stocker, Mark A Perrella
Sep 10, 2020·International Journal of Molecular Sciences·Neelu BatraAi-Ming Yu
Mar 19, 2020·International Journal of Molecular Medicine·Jin ZhouRudan Zhou
Jul 3, 2020·Malaria Journal·Isaclaudia G de Azevedo-QuintanilhaHugo C Castro-Faria-Neto
Jan 28, 2021·Journal of Clinical Medicine·Marie-Thérèse Hopp, Diana Imhof
Feb 23, 2020·Free Radical Biology & Medicine·Hirofumi HiraoJerzy W Kupiec-Weglinski
Apr 4, 2021·International Journal of Molecular Sciences·Patrycja KaczaraStefan Chlopicki
May 1, 2021·Journal of Clinical Medicine·Marco CapecchiIda Martinelli
May 22, 2021·International Immunopharmacology·Salvatore ChirumboloSergio Pandolfi

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