PMID: 3754136Jan 15, 1986Paper

Induction of hepatic and renal ornithine decarboxylase by cobalt and other metal ions in rats

The Biochemical Journal
T YoshidaY Kuroiwa

Abstract

We previously showed that Cd2+ is able to induce hepatic and renal ornithine decarboxylase (ODC). In addition to Cd2+, the administration of Co2+ and other metal ions such as Se2+, Zn2+ and Cr2+ produced a significant increase of hepatic and/or renal ODC activity. Of the metal ions used in this study, Co2+ produced the greatest increase of ODC activity. The maximum increases in hepatic and renal ODC activity, to respectively 70 and 14 times the control values in male rats, were observed 6 h after the administration of Co2+. A similar response was seen in the liver, but not in the kidney, of female rats. Thereafter, ODC activity gradually returned to control values in the liver, but it was profoundly decreased to 7% of the control value at 24 h in the kidney. The pretreatment of animals with either actinomycin D or cycloheximide almost completely blocked the Co2+-mediated increase of ODC activity. Co2+ complexed with either cysteine or glutathione (GSH) failed to induce ODC. Depletion of hepatic GSH content by treatment of rats with diethyl maleate greatly enhanced the inducing effect of Co2+ on ODC. The inhibitors of ODC, 1,3-diaminopropane and alpha-difluoromethylornithine, were able to inhibit the induction of the enzyme, wit...Continue Reading

Citations

Feb 1, 1988·Toxicology and Applied Pharmacology·T YoshidaY Kuroiwa
Feb 1, 1993·Amino Acids·C StefanelliC M Caldarera
Oct 1, 1992·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·A T LyosC M Henley
Jan 1, 1994·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·C M Henley
Jan 1, 1989·Chemico-biological Interactions·S NumazawaY Kuroiwa
Jan 1, 1988·The International Journal of Biochemistry·N G AbrahamS Shibahara

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