Induction of hepatic heme oxygenase-1 and ferritin in rats by cancer chemopreventive dithiolethiones

Carcinogenesis
T PrimianoT R Sutter

Abstract

Treatment of rats with the cancer chemopreventive agent 1,2-dithiole-3-thione (D3T) resulted in a significant increase in hepatic heme oxygenase (HO) activity, which corresponded to increased protein levels of HO-1. Upon further analysis of proteins related to heme metabolism, the level of ferritin, the major iron storage protein in liver, was also found to be elevated. Diminished levels of intracellular free iron were monitored by EPR spectroscopy at times after administration of D3T that suggested that increased ferritin content sequesters intracellular iron. The increased levels of protein were associated with increased levels of steady-state RNA of HO-1 and the light (FL) and heavy (FH) subunits of ferritin. A direct relationship between enhanced rates of gene transcription and elevated levels of HO-1 and ferritin RNA was found. The inductions of FL and FH, but not HO-1, were sensitive to cycloheximide, suggesting that in vivo these genes are regulated by distinct D3T-responsive transcriptional mechanisms. The known protective roles for induced HO-1 and ferritin in cellular stress have been suggested to include increased levels of the antioxidant bilirubin and enhanced sequestration of intracellular iron into ferritin, whic...Continue Reading

Citations

Jun 10, 2008·Marine Biotechnology·Brandon W KusikAva J Udvadia
May 10, 2005·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Lalita BharadwajAdnan Ali
Jun 7, 2003·Advances in Enzyme Regulation·John WilkinsonFrank M Torti
Feb 19, 1998·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·T PrimianoT W Kensler
May 10, 2000·Free Radical Biology & Medicine·M A OtienoK Z Guyton
Aug 6, 2002·Free Radical Biology & Medicine·Paolo Arosio, Sonia Levi
Dec 17, 2005·Antioxidants & Redox Signaling·Auemduan PrawanYoung-Joon Surh
May 8, 2010·Antioxidants & Redox Signaling·John D HayesAlbena T Dinkova-Kostova
Nov 26, 2009·Molecular and Cellular Biology·Scott F Leiser, Richard A Miller
Sep 14, 2006·Annual Review of Pharmacology and Toxicology·Thomas W KenslerShyam Biswal
Mar 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·A T Dinkova-KostovaP Talalay
Mar 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·M Ramos-GomezT W Kensler
Oct 12, 2005·Proceedings of the National Academy of Sciences of the United States of America·Korry J Hintze, Elizabeth C Theil
May 13, 1997·Proceedings of the National Academy of Sciences of the United States of America·W W Wasserman, W E Fahl
Feb 9, 2010·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Kiyun ParkInn-Sil Kwak
Mar 10, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Monika A PapiezGabriel Nowak
Jul 22, 2004·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Toru YanagawaMasayuki Yamamoto
May 26, 2005·Cancer Letters·Jeong-Sang Lee, Young-Joon Surh
Mar 8, 2000·Biochemical Pharmacology·B Drukarch, F L van Muiswinkel
Aug 29, 2006·Free Radical Biology & Medicine·Bente GlintborgHenrik E Poulsen
Mar 21, 2006·Free Radical Biology & Medicine·Yan JiaoSuzy V Torti
Sep 28, 2006·Journal of Biochemistry and Molecular Biology·Ebenezer Olatunde Farombi, Young Joon Surh
Aug 11, 2017·Antioxidants & Redox Signaling·Michael John Kerins, Aikseng Ooi
Feb 1, 2019·Arteriosclerosis, Thrombosis, and Vascular Biology·Katalin Éva SikuraJózsef Balla
Sep 13, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·Xuchen ZhangPatty J Lee
May 3, 2002·Blood·Frank M Torti, Suzy V Torti
Nov 19, 2002·The Journal of Biological Chemistry·E Christine PietschSuzy V Torti
May 10, 2015·American Journal of Physiology. Lung Cellular and Molecular Physiology·Thomas E SussanShyam Biswal
Jun 20, 2020·Nanotoxicology·Robert A YokelUschi M Graham
Nov 27, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sarmistha SahaLuciano Saso
Oct 20, 2020·Placenta·Rikako InoueReiko Akagi

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