Induction of hepatic tumors with butylated hydroxyanisole in the self-fertilizing hermaphroditic fish Rivulus ocellatus marmoratus

Japanese Journal of Cancer Research : Gann
E H ParkY N Cha

Abstract

The three-day-old larvae of self-fertilizing hermaphroditic fish Rivulus ocellatus marmoratus were fed a diet containing the antioxidant butylated hydroxyanisole (BHA) at levels of 0.01-0.8% for 12 days. Six months after BHA administration, hepatic tumors were found in all groups of BHA-treated fish. The BHA-induced tumor incidences were clearly dose-dependent. These results show that dietary BHA is hepatocarcinogenic in Rivulus even at 0.01% dose.

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Citations

Oct 29, 1999·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·G M WilliamsJ Whysner
Oct 24, 2007·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Young-Mi LeeJae-Seong Lee
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Jul 2, 2019·Journal of Fish Biology·Irene Yin-LiaoFrédéric Laberge
Nov 27, 2019·The Journal of Experimental Biology·Giulia S Rossi, Patricia A Wright
Feb 8, 2020·The Journal of Experimental Biology·Shelly C McCainRyan L Earley
Apr 6, 2016·The Journal of Experimental Biology·Benjamin M Perlman, Miriam A Ashley-Ross
Apr 1, 1993·Zeitschrift Für Lebensmittel-Untersuchung Und -Forschung·R Kahl, H Kappus

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