PMID: 8977461Dec 1, 1996Paper

Induction of hepatic uptake of lipoprotein(a) by cholesterol-derivatized cluster galactosides

Arteriosclerosis, Thrombosis, and Vascular Biology
E A BiessenT J van Berkel

Abstract

We have previously developed triantennary galactosides [TG(4A)C and TG(20A)C] that lower cholesterol levels by inducing liver uptake of lipoproteins via galactose-recognizing hepatic receptors. In this study, we have investigated whether this strategy could also be applied to reduce elevated serum levels of the atherogenic lipoprotein(a) [Lp(a)]. Both TG(4A)C and TG(20A)C could be incorporated into Lp(a). Incorporation of these glycolipids induced a rapid clearance of Lp(a). Concomitantly, the hepatic uptake of 125I-Lp(a) was enhanced from 4 +/- 1% to 80 +/- 4% of the injected dose for TG(4A)C (P < .0001) and to 17 +/- 4% of the injected dose for TG(20A)C (P < .006). TG(4A)C was apparently more effective in accelerating the serum decay of 125I-Lp(a), which may be caused by the higher hydrophobicity of this glycolipid relative to TG(20A)C. The TG(4A)C- and TG(20A)C-induced stimulation of the serum decay and liver uptake of 125I-Lp(a) could be significantly inhibited (> 85%) by preinjection of N-acetyl-galactosamine (150 mg), indicating that galactose-recognizing receptors are involved in the liver uptake of the glycolipid/Lp(a) complexes. The TG(4A)C-induced liver uptake of 125I-Lp(a) could be ascribed mainly to Kupffer cells (7...Continue Reading

References

May 12, 1975·Analytical Biochemistry·T G RedgraveC E West
May 1, 1987·The Biochemical Journal·T J van BerkelH G van Eijk
Sep 1, 1989·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·M RathU Beisiegel
Nov 17, 1989·Science·G Utermann
Sep 1, 1989·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·G L CushingJ D Morrisett
Nov 1, 1985·Atherosclerosis·A GurakarH B Brewer
Aug 1, 1987·The Journal of Clinical Investigation·G UtermannC Seitz
Aug 1, 1986·Experimental Cell Research·J Schlepper-SchäferV Kolb-Bachofen
Apr 4, 1986·Science·M S Brown, J L Goldstein
Apr 15, 1981·Experientia·M K BijsterboschM Gruber
Jan 1, 1981·Atherosclerosis·G M KostnerG B Qunici
Apr 1, 1994·The Biochemical Journal·J KuiperT J Van Berkel
Jun 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M N PietersT J Van Berkel
Nov 1, 1955·The American Journal of Physiology·W O CASTERW D ARMSTRONG

❮ Previous
Next ❯

Citations

Nov 9, 2016·Journal of Lipid Research·Karam M Kostner, Gert M Kostner

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.