PMID: 9187296May 17, 1997Paper

Induction of hepatocyte proliferation after partial hepatectomy is accompanied by a markedly reduced expression of phosphatidylethanolamine N-methyltransferase-2

Biochimica Et Biophysica Acta
M HouwelingD E Vance

Abstract

Expression of phosphatidylethanolamine N-methyltransferase (PEMT)-2 in rat hepatoma cells caused an increase in the time for cell division from 18 to 50 h [Cui et al. (1994) J. Biol. Chem. 269, 24531-24533]. We investigated whether or not a similar inverse relationship might exist for liver proliferation in vivo. Thus, partial hepatectomized rats were used to investigate the expression of PEMT2 during liver regeneration. Enhanced biosynthesis of phosphatidylcholine after partial hepatectomy was due to increased activity and amount of CTP:phosphocholine cytidylyltransferase. On the other hand the total activity of PEMT was markedly decreased during the first days of rat liver regeneration. Maximal decrease of total PEMT activity (45%) and loss of PEMT2 protein (90%) coincided with maximal DNA synthesis and CTP:phosphocholine cytidylyltransferase activity 24 h after partial hepatectomy in both male and female rats. Supplementing dietary choline in the diets of female rats shifted this pattern from 24 h to 36 h after partial hepatectomy, whereas the pattern in male rats was not affected. Northern blot studies showed that the amount of PEMT2 mRNA was decreased accordingly, suggesting regulation of the amount and activity of PEMT2 a...Continue Reading

References

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Citations

Nov 25, 1997·Biochimica Et Biophysica Acta·D E VanceZ Cui
Jan 18, 2003·Biochimica Et Biophysica Acta·Zheng Cui, Martin Houweling
Jul 5, 2003·Biochimica Et Biophysica Acta·Mohammad KarimSuzanne Jackowski
Dec 16, 1997·Proceedings of the National Academy of Sciences of the United States of America·C J WalkeyD E Vance
Nov 12, 2010·Journal of Lipid Research·Christopher J PynnAnthony D Postle
Apr 19, 2006·In Vitro Cellular & Developmental Biology. Animal·Hisae Kume, Hajime Sasaki
Aug 29, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Lars E Schmidt, Kim Dalhoff
Sep 29, 2009·Prostaglandins, Leukotrienes, and Essential Fatty Acids·S AbelW C A Gelderblom
Jun 8, 2006·Biochemical and Biophysical Research Communications·Barbara MarengoLuciana Tessitore
Aug 11, 2012·Biochimica Et Biophysica Acta·Dennis E Vance
Nov 5, 2013·Biochimica Et Biophysica Acta·Dennis E Vance
Jan 29, 2013·Critical Reviews in Biochemistry and Molecular Biology·Neale D Ridgway
Mar 12, 2008·Annual Review of Nutrition·José M MatoShelly C Lu
Jul 7, 2007·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Valéria Cristina Soares FurtadoAntonio Carlos Iglesias
Mar 31, 2004·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Jean E Vance, Dennis E Vance
Apr 29, 1998·Current Opinion in Lipidology·D E Vance, C J Walkey
Oct 9, 1998·The Journal of Biological Chemistry·C J WalkeyD E Vance
Oct 7, 2020·The American Journal of Clinical Nutrition·Kevin C Klatt
Aug 12, 2020·The American Journal of Clinical Nutrition·Kevin C W GossAnthony D Postle
Feb 15, 2020·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·Christa Buechler, Charalampos Aslanidis
Feb 28, 2002·The Journal of Biological Chemistry·Cynthia J DeLongZheng Cui

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