Induction of hibernation-like hypothermia by central activation of the A1 adenosine receptor in a non-hibernator, the rat

The Journal of Physiological Sciences : JPS
Hiroki ShimaokaYasutake Shimizu

Abstract

Central adenosine A1-receptor (A1AR)-mediated signals play a role in the induction of hibernation. We determined whether activation of the central A1AR enables rats to maintain normal sinus rhythm even after their body temperature has decreased to less than 20 °C. Intracerebroventricular injection of an adenosine A1 agonist, N6-cyclohexyladenosine (CHA), followed by cooling decreased the body temperature of rats to less than 20 °C. Normal sinus rhythm was fundamentally maintained during the extreme hypothermia. In contrast, forced induction of hypothermia by cooling anesthetized rats caused cardiac arrest. Additional administration of pentobarbital to rats in which hypothermia was induced by CHA also caused cardiac arrest, suggesting that the operation of some beneficial mechanisms that are not activated under anesthesia may be essential to keep heart beat under the hypothermia. These results suggest that central A1AR-mediated signals in the absence of anesthetics would provide an appropriate condition for maintaining normal sinus rhythm during extreme hypothermia.

References

Jan 1, 1995·Journal of Electrocardiology·I GussakB R Chaitman
Feb 22, 2000·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·W K MilsomM B Harris
Jul 5, 2002·The American Journal of Emergency Medicine·Amal MattuAndrew D Perron
Oct 1, 1963·The Journal of Physiology·C P LYMAN, R C O'BRIEN
Sep 25, 2003·Physiological Reviews·Hannah V CareySandra L Martin
Feb 24, 2004·Annual Review of Physiology·Fritz Geiser
May 25, 2005·Brain Research·Yutaka TamuraHirohito Shiomi
May 19, 2007·Brain, Behavior and Evolution·K W S AshwellC R R Watson
Nov 23, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Alexander MertensMichael Meyer
Jul 4, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Seiji MiyazawaTadashi Takewaki
Nov 6, 2008·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Vadim V FedorovIgor R Efimov
Oct 13, 2009·Current Neurology and Neuroscience Reports·Hoang Nguyen, Jonathan G Zaroff
Jul 29, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tulasi R JinkaKelly L Drew
Jul 13, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Benjamin W Iliff, Steven J Swoap
Sep 6, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Domenico TuponeShaun F Morrison

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Citations

Jun 13, 2019·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Yuuki HoriiYasutake Shimizu
Dec 21, 2018·Pflügers Archiv : European journal of physiology·A ChoukèrG Heldmaier
Dec 15, 2020·Nature Communications·Zhi ZhangStephanie M Correa
Apr 1, 2021·The Journal of Physiological Sciences : JPS·Hiroki ShimaokaYasutake Shimizu
Jun 19, 2021·Neuroscience and Biobehavioral Reviews·Matteo CerriRoberto Amici

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