PMID: 7027259Jul 1, 1981Paper

Induction of high serum levels of retroviral env gene products (gp70) in mice by bacterial lipopolysaccharide

Proceedings of the National Academy of Sciences of the United States of America
I HaraF J Dixon

Abstract

In the present study, mice each given a single intraperitoneal injection of Escherichia coli lipopolysaccharide (LPS) responded with increased serum levels of the major envelope glycoprotein, gp70, of endogenous retrovirus. Concentrations of gp70 in their sera began to increase 4 hr after LPS injection, reached maximal 5- to 15-fold increases after 12--24 hr, and returned to the preinjection levels within 3 days. This response occurred only in the strains characterized by high base line levels of serum gp70 (greater than 10 micrograms/ml) such as NZB, NZB X NZW F1, BXSB, MRL, NZW, DBA/2, LG, 129(GIX+), and C57BL/6(GIX+). However, strains such as DBA/1, C3H/St, BALB/c, C57BL/6(GIX-), and 129(GIX-) with lower base line levels of serum gp70 (less than 5 micrograms/ml) made little or no response. This serum gp70 induced by LPS was structurally similar to the gp70 of NZB xenotropic virus that is dominantly expressed in sera from virtually all strains of mice. However, (i) the induced gp70 was virion-free; (ii) xenotropic virus was not isolatable from BXSB, MRL/1, or 129(GIX+) mice injected with LPS; and (iii) amounts of the major structural viral protein, p30, did not increase correspondingly in sera. All of these findings indicate ...Continue Reading

References

Jan 1, 1975·The Journal of Experimental Medicine·B C Del VellanoF J Dixon
Jan 1, 1975·The Journal of Experimental Medicine·Y ObataE A Boyse
Feb 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·C MoroniD Martin
Oct 15, 1976·Virology·R M WelshM B Oldstone
Nov 1, 1976·Virology·M Strand, J T August
Oct 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·J H ElderW P Rowe

❮ Previous
Next ❯

Citations

Jan 1, 1983·Immunogenetics·N MaruyamaF J Dixon
Jan 1, 1983·Immunogenetics·N Maruyama, C O Lindstrom
May 1, 1992·Molecular Immunology·K ShigemotoN Maruyama
Oct 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·C BlattM I Simon
Feb 1, 1982·The Journal of Experimental Medicine·I HaraF J Dixon
Aug 30, 1988·Biochemical and Biophysical Research Communications·Y DeguchiS Kishimoto
Jul 28, 2010·Autoimmunity Reviews·Lucie BaudinoShozo Izui
Oct 23, 2009·Journal of Autoimmunity·Marie-Laure Santiago-RaberShozo Izui
May 1, 1982·Clinical Immunology and Immunopathology·A N TheofilopoulosF J Dixon
Jun 6, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kumiko YoshinobuShozo Izui
Apr 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Robert J RigbyTimothy J Vyse
Jan 7, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shuichi KikuchiShozo Izui
Aug 8, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lucie BaudinoShozo Izui
Mar 7, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yoshitomo HamanoKazuo Suzuki
Jul 21, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·R M TuckerB L Kotzin
Sep 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Catherine LaporteLuc Reininger

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.