PMID: 8971941Jan 1, 1996Paper

Induction of histamine release from rat mast cells by bradykinin analogues

Peptides
G VietinghoffS Reissmann

Abstract

Independently of their agonistic or antagonistic activity on different isolated tissue preparations, the kinin analogues investigated induce histamine release on rat peritoneal mast cells. The effectivity of most compounds is 10 to 100 times higher than that of bradykinin. Beside the positively charged amino acids, the elongation at the N-terminus with hydrophobic amino acids and the replacement of amino acids in the bradykinin sequence (especially at position 7) with aromatic residues is important for a high histamine-releasing activity.

References

Mar 1, 1991·British Journal of Pharmacology·F J HockJ Knolle
Jan 15, 1989·Biochemical Pharmacology·I D LawrenceD Proud
Apr 1, 1989·Agents and Actions·M K ChurchR C Benyon
Jan 1, 1983·Annual Review of Pharmacology and Toxicology·D LagunoffG Read
Jan 1, 1994·Immunopharmacology·M MousliC Bronner
Jan 1, 1995·Biological Chemistry Hoppe-Seyler·T SteinmetzerS Reissmann
Jan 1, 1995·Biological Chemistry Hoppe-Seyler·C SchumannS Reissmann

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Citations

Jun 10, 1998·Journal of Peptide Science : an Official Publication of the European Peptide Society·G GreinerS Reissmann
Jun 23, 2009·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Kumi MoriyamaPamela Pierce Palmer
Aug 29, 2003·Medical Hypotheses·K UchidaS Takagi
Sep 27, 2016·Pulmonary Pharmacology & Therapeutics·Jatinder SinghDhandeep Singh

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