Induction of HIV-1 MPR(649-684)-specific IgA and IgG antibodies in caprine colostrum using a peptide-based vaccine

Vaccine
Stephanie M DoroskoRuth I Connor

Abstract

Induction of antigen-specific antibodies against HIV-1 in colostrum and milk may help prevent breast milk transmission of the virus. A peptide vaccine against the HIV-1 gp41 membrane proximal region (MPR(649-684)) was evaluated as proof-of-principle in a caprine model. Pregnant Alpine/Saanen goats were immunized with MPR(649-684) peptide conjugated to KLH using alum adjuvant. Immunizations were intramuscular, intranasal, and in the supramammary lymph node region. Samples collected after parturition demonstrated the presence of MPR(649-684)-specific antibodies in colostrum and serum. These results support the concept that a peptide vaccine can effectively induce MPR(649-684)-specific sIgA and IgG in the colostrum of a lactating species.

References

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Citations

Mar 29, 2014·Current Opinion in HIV and AIDS·M Anthony Moody
May 27, 2014·Pediatric Research·Monisha P GidvaniCaroline L S George
May 7, 2014·Immunology and Cell Biology·Wendy R WinnallStephen J Kent
Nov 26, 2010·Expert Review of Vaccines·Carla HerbertsMarijke Faas
Jan 19, 2012·Nutrients·Walter L Hurley, Peter K Theil

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