Induction of hot flashes in premenopausal women treated with a long-acting GnRH agonist

The Journal of Clinical Endocrinology and Metabolism
J DeFazioH L Judd

Abstract

To examine the relationship between the occurrence of menopausal hot flashes and the pulsatile release of LH, we have investigated the serum hormone levels and the occurrence of hot flashes by objective recordings in five women with endometriosis given daily injections of a long-acting GnRH agonist (GnRH-a) for 28 days. Results were compared to the findings made in 25 young women 6-8 weeks after bilateral oophorectomy. Serum levels of estrone and estradiol were similar in the subjects given GnRH-a and the women who underwent a surgical castration. In comparison with values before GnRH-a administration, the mean FSH level was lower whereas the mean LH concentration was significantly higher (P less than 0.01) on the last day of therapy. The coefficients of variations of both gonadotropins measured during 4-h sampling periods at 20-min intervals before and at the end of GnRH-a administration were significantly reduced (P less than 0.01) with therapy. During the total of 20 h of frequent sampling in the 5 subjects, 15 pulses (20% rise from nadir) of LH and 12 pulses of FSH were detected before GnRH-a, whereas only 2 and 8 pulses, respectively, were observed on day 28 of treatment. Hot flashes were observed in both groups of patient...Continue Reading

Citations

Jun 16, 2001·American Journal of Human Biology : the Official Journal of the Human Biology Council·R R Freedman
Feb 1, 1990·Journal of Behavioral Medicine·L C SwartzmanE Kemmann
Jan 20, 1991·The New England Journal of Medicine·P M Conn, W F Crowley
Sep 23, 2003·Nursing Research·Sharon L Dormire, Nancy King Reame
Jan 13, 2004·Menopause : the Journal of the North American Menopause Society·UNKNOWN North American Menopause Society
Aug 5, 2008·Clinical Obstetrics and Gynecology·Nanette Santoro
Jan 1, 1990·Annals of the New York Academy of Sciences·F Kronenberg
Jul 23, 1983·British Medical Journal·J Ginsburg
Sep 10, 2013·The Journal of Steroid Biochemistry and Molecular Biology·Robert R Freedman
Feb 7, 2003·Journal of Women's Health·Murray A Freedman
Feb 28, 2002·Expert Opinion on Investigational Drugs·Enrico Carmina
Dec 9, 2008·Climacteric : the Journal of the International Menopause Society·M Andrikoula, G Prelevic
Sep 29, 2012·Climacteric : the Journal of the International Menopause Society·P van GastelH de Boer
May 1, 1987·American Journal of Obstetrics and Gynecology·R W Rebar, I B Spitzer
Aug 9, 2003·Journal of Obstetric, Gynecologic, and Neonatal Nursing : JOGNN·Sharon L Dormire
Jan 18, 2006·The American Journal of Medicine·Robert R Freedman
Mar 1, 1985·Clinical Endocrinology·R F Casper, S S Yen
Feb 1, 1987·Baillière's Clinical Endocrinology and Metabolism·H M Fraser, D T Baird
Mar 23, 2017·The Journal of Clinical Endocrinology and Metabolism·Juki NgCheri E Klein
May 1, 1986·British Journal of Obstetrics and Gynaecology·R I McLachlanH G Burger
May 2, 2001·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·E Carmina
Jan 1, 1989·Progress in Clinical and Biological Research·B Walsh, I Schiff
Sep 30, 2016·The Journal of Clinical Endocrinology and Metabolism·Hadine JoffeLee S Cohen
Jan 1, 1989·Archives of Gynecology and Obstetrics·M H Birkhäuser
May 27, 1999·Annals of Medicine·J A Empson, D W Purdie
Jan 1, 1990·Annals of the New York Academy of Sciences·B Walsh, I Schiff
Sep 4, 2003·Journal of Agricultural and Food Chemistry·Joanna E BurdetteJudy L Bolton

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