PMID: 6980230Aug 1, 1982Paper

Induction of human B cell antigens in non-T cell acute lymphoblastic leukemia

The Journal of Clinical Investigation
L M NadlerS F Schlossman

Abstract

Leukemic cells from 70% of patients with Ia+CALLA+ non-T cell acute lymphoblastic leukemia (ALL) express an antigen (B1) found on all normal B lymphocytes. In this study, ALL cells that do not express the B1 antigen were studied in an attempt to further elucidate the cellular lineage of these tumors. Non-T cell ALL lines and tumor cells isolated from patients with non-T cell ALL that are Ia + CALLA + B1- were studied in vitro with a variety of agents known to promote cellular differentiation. Phorbol diester (TPA) or phytohemagglutinin conditioned leukocyte culture media were capable of inducing the expression of B1 on all four non-T cell ALL lines tested. In contrast, B1 could not be induced under the identical conditions on a promyelocytic leukemia line or a T cell lymphoblastic leukemia line. With the induction of B1 on non-T cell ALL lines, cytoplasmic mu-heavy chain (c mu) became undetectable, whereas the expression of CALLA and Ia were unchanged. The expression of B1 was accompanied by a decrease of cellular proliferation and DNA synthesis, but not significant morphologic changes were noted. In addition, no other B or T cell antigens were detected. The cellular origin of non-T cell ALL was further investigated using tumor...Continue Reading

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Citations

May 1, 1984·Journal of Clinical Immunology·J OkamuraE W Gelfand
Jul 1, 1983·Journal of Clinical Immunology·G B Melink, T W LeBien
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Dec 1, 1984·Scandinavian Journal of Immunology·J A SognH Kulaga

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