Induction of hypertension blunts baroreflex inhibition of vasopressin neurons in the rat

The European Journal of Neuroscience
Su Young HanC H Brown

Abstract

Vasopressin secretion from the posterior pituitary gland is determined by action potential discharge of hypothalamic magnocellular neurosecretory cells. Vasopressin is a potent vasoconstrictor, but vasopressin levels are paradoxically elevated in some patients with established hypertension. To determine whether vasopressin neurons are excited in hypertension, extracellular single-unit recordings of vasopressin neurons from urethane-anaesthetized Cyp1a1-Ren2 rats with inducible angiotensin-dependent hypertension were made. The basal firing rate of vasopressin neurons was higher in hypertensive Cyp1a1-Ren2 rats than in non-hypertensive Cyp1a1-Ren2 rats. The increase in firing rate was specific to vasopressin neurons because oxytocin neuron firing rate was unaffected by the induction of hypertension. Intravenous injection of the α1-adrenoreceptor agonist, phenylephrine (2.5 μg/kg), transiently increased mean arterial blood pressure to cause a baroreflex-induced inhibition of heart rate and vasopressin neuron firing rate (by 52 ± 9%) in non-hypertensive rats. By contrast, intravenous phenylephrine did not inhibit vasopressin neurons in hypertensive rats, despite a similar increase in mean arterial blood pressure and inhibition of h...Continue Reading

References

May 1, 1992·Canadian Journal of Physiology and Pharmacology·A V Ferguson, K M Wall
Nov 1, 1991·Hypertension·A Zanchetti, G Mancia
Feb 1, 1989·Hypertension·M Morris, N Alexander
Nov 1, 1988·Hypertension·C D SladekM L Mangiapane
Oct 1, 1967·The Journal of Obstetrics and Gynaecology of the British Commonwealth·M P Embrey, J C Moir
Nov 1, 1981·Neuroendocrinology·R J Bicknell, G Leng
Dec 1, 1980·Neuroendocrinology·M L Mangiapane, J B Simpson
Feb 14, 1995·Proceedings of the National Academy of Sciences of the United States of America·S NielsenM A Knepper
Mar 1, 1993·Journal of the Autonomic Nervous System·T A Day, J R Sibbald
May 1, 1997·Journal of Hypertension·G BakrisH Gavras
Oct 23, 1997·Brain Research. Molecular Brain Research·D Plochocka-Zulinska, T L Krukoff
Dec 31, 1998·Journal of Neuroendocrinology·M Ludwig
Jul 13, 2001·The Journal of Biological Chemistry·S KantachuvesiriJ J Mullins
Sep 28, 2001·Experimental Neurology·R R Grindstaff, J T Cunningham
Oct 3, 2001·Physiological Reviews·H E de Wardener
Jan 29, 2002·Anesthesia and Analgesia·Koji Hara, R Adron Harris
Nov 19, 2003·The European Journal of Neuroscience·Philip M BullJohn A Russell
May 18, 2004·The Journal of Physiology·Nancy SabatierGareth Leng
Jul 29, 2008·Progress in Brain Research·Colin H BrownMike Ludwig
Oct 14, 2009·The Journal of Physiology·Victoria ScottColin H Brown
Jul 7, 2010·The Journal of Physiology·Glenn M Toney, Sean D Stocker
Mar 12, 2011·American Journal of Hypertension·Markus P SchlaichMurray D Esler
Sep 16, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jeong Sook KimYang In Kim
Oct 14, 2011·American Journal of Physiology. Renal Physiology·Catherine G Howard, Kenneth D Mitchell
Nov 22, 2012·Autonomic Neuroscience : Basic & Clinical·Kenta YamamotoSteve Mifflin
Mar 7, 2013·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Bart F J HeijnenBen J A Janssen
Aug 28, 2013·Pflügers Archiv : European journal of physiology·Su Young HanDaryl O Schwenke

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Citations

Feb 27, 2018·Current Hypertension Reports·Maja LozićNina Japundžić-Žigon
Jun 6, 2019·Journal of Neuroendocrinology·Young-Beom KimYang In Kim
Feb 15, 2020·American Journal of Physiology. Heart and Circulatory Physiology·E Szczepanska-SadowskaA Wsol
May 15, 2020·Journal of Neuroendocrinology·Colin H BrownJavier E Stern
Jan 7, 2017·Clinical Science·Sinan Khor, Dongsheng Cai
Apr 3, 2021·Autonomic Neuroscience : Basic & Clinical·Bryan K BeckerDavid M Pollock
Feb 18, 2021·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Alexandria B MarcianteJ Thomas Cunningham

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