Induction of hypothalamic serum- and glucocorticoid-induced protein kinase-1 gene expression and its relation to plasma des-acyl ghrelin in energy homeostasis in mice

Biochemical and Biophysical Research Communications
Katsunori NonogakiYoshitomo Oka

Abstract

Serum- and glucocorticoid-induced protein kinase (SGK) is a serine/threonine-specific protein kinase that is transcriptionally regulated by serum, glucocorticoids, and mineral corticoids. Here, we report that fasting or obesity with hyperphagia increased hypothalamic SGK-1 gene expression. Hypothalamic SGK-1 mRNA levels were proportional to daily food intake and body weights in C57BL6J mice, KK mice, and KKA(y) mice matched for age. Plasma des-acyl ghrelin, but not active ghrelin, levels were inversely proportional to daily food intake and body weights among these animals. The increases in hypothalamic SGK-1 gene expression in these animals were not accompanied by increases in plasma corticosterone levels. Under conditions of increased energy usage such as fasting, hypothalamic SGK-1 gene expression and plasma des-acyl ghrelin levels were positively correlated while during conditions of increased energy storage, they were negatively correlated. These results suggest that hypothalamic SGK-1 gene is a novel candidate gene involving in energy homeostasis in mice.

References

Sep 7, 2002·Hypertension·Andreas BusjahnFlorian Lang
Apr 7, 2005·FEBS Letters·Shigenori MurataKenichi Matsubara
Jun 14, 2005·Brain Research. Molecular Brain Research·Eisuke KoyaAugust B Smit
Jul 15, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Volker VallonFlorian Lang

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Citations

Aug 12, 2010·International Journal of Peptides·Susana Sangiao-Alvarellos, Fernando Cordido
Jun 10, 2010·The Journal of Physiology·Florian LangUndine E Lang
Oct 1, 2011·Archives of Gerontology and Geriatrics·Yosuke AkimotoKyoko Miyasaka
May 12, 2009·Peptides·Tobias InhoffPeter Kobelt
Jul 2, 2008·Annals of the New York Academy of Sciences·K BefortB L Kieffer
Dec 3, 2014·Psychoneuroendocrinology·En-Ju D LinMatthew J During

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