Induction of IκBζ Augments Cytokine and Chemokine Production by IL-33 in Mast Cells

The Journal of Immunology : Official Journal of the American Association of Immunologists
Hiromi Ohto-OzakiTsukasa Ohmori

Abstract

IκBζ (encoded by the Nfkbiz) is a member of the nuclear IκB family, which is involved in the expression of secondary response genes based on signals from TLR or IL-1R. ST2L, an IL-33R, is a member of the IL-1R family and abundantly expressed in tissue-resident immune cells, such as mast cells and innate lymphoid cells; however, its downstream signaling pathway remains unelucidated. In this study, we examined the role of IκBζ in ST2L-mediated cytokine and chemokine production in mast cells. Murine bone marrow cells were differentiated ex vivo into bone marrow-derived mast cells (BMMCs). The treatment of BMMCs with IL-33 transiently induced robust IκBζ expression. Of the 40 cytokines and chemokines examined using a cytokine and chemokine array, the concentrations of IL-6, IL-13, CCL2, CCL3, and TNF-α in the supernatant were augmented by IL-33. The deletion of IκBζ in BMMCs resulted in a significant reduction of the production of these mediators and the expression of their mRNA. NF-κB p50 but not p65 translocated to the nucleus by IL-33 and was not affected by the deletion of IκBζ. However, induction of IκBζ and the resultant cytokine and chemokine productions were significantly inhibited by pretreatment with an NF-κB inhibitor. T...Continue Reading

References

Aug 27, 1991·Biochimica Et Biophysica Acta·S TominagaT Tetsuka
Sep 8, 1995·Science·R KühnK Rajewsky
Mar 30, 2001·The Journal of Biological Chemistry·H HarutaK Todokoro
Sep 11, 2004·Biochemical and Biophysical Research Communications·Hiroyuki MatsumuraMasaru Okabe
Aug 22, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Brian O BarnsteinJohn J Ryan
Oct 10, 2006·Vitamins and Hormones·Tatsushi Muta
Aug 19, 2007·Laboratory Investigation; a Journal of Technical Methods and Pathology·Motoyasu IikuraSusumu Nakae
Sep 21, 2007·Journal of Leukocyte Biology·Lien H HoSusumu Nakae
Nov 1, 2007·Transgenic Research·Julia ScholtenAxel Roers
Jan 19, 2010·Nature Reviews. Immunology·Foo Y LiewIain B McInnes
Apr 3, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Dominic G HildebrandKlaus Schulze-Osthoff
May 21, 2013·The Journal of Allergy and Clinical Immunology·Ilkka S JunttilaWilliam E Paul
Sep 13, 2013·Neoplasia : an International Journal for Oncology Research·Ryuichiro KimuraNaoki Mori
Feb 11, 2015·Immunology Letters·Jingli LuXiaojian Zhang
Jun 18, 2015·Immunity·Ari B MolofskyRichard M Locksley
Oct 2, 2015·Clinical and Translational Allergy·Rohit SalujaMarcus Maurer
Oct 16, 2015·Proceedings of the National Academy of Sciences of the United States of America·Claus JohansenLars Iversen
Jan 19, 2016·Frontiers in Immunology·Melissa Krystel-WhittemoreJohn G Wood
Jan 26, 2016·Immunology Letters·Michaela AnnemannIngo Schmitz
Oct 4, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sebastian DrubeThomas Kamradt
Oct 14, 2016·Advances in Experimental Medicine and Biology·Amir S Yazdi, Kamran Ghoreschi
Jan 19, 2017·Oncotarget·Ki Wung ChungHae Young Chung
Nov 21, 2017·Cytokine & Growth Factor Reviews·Rinkesh Kumar GuptaPremendra D Dwivedi
Dec 17, 2017·Immunological Reviews·Corinne Cayrol, Jean-Philippe Girard
Feb 13, 2018·Immunological Reviews·Kaori MukaiStephen J Galli
Jul 11, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Wen DingLi-Xia Xiong
Aug 24, 2018·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Wei-Yu ChenLung-Chih Li
Sep 19, 2018·Proceedings of the National Academy of Sciences of the United States of America·Anne MüllerDaniela Kramer
Oct 3, 2018·Nature Communications·Sarah E ArthurRyan D Morin

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