PMID: 6166725Jul 1, 1981Paper

Induction of idiotype-bearing, nuclease-specific helper T cells by in vivo treatment with anti-idiotype

The Journal of Experimental Medicine
G G MillerD H Sachs

Abstract

Treatment of BALB/c mice with purified pig anti-(BALB/c anti-nuclease) anti-idiotypic antibodies has been found to induce the appearance of idiotype-bearing immunoglobulins (Id') in the serum of these mice in the absence of detectable antigen binding activity. This phenomenon appeared to require T cells in the hosts because no Id' was detected in the serum of nude mice similarly treated. Furthermore, the spleens of BALB/c mice treated with anti-idiotype were found to contain helper T cells capable of providing help in an in vitro plaque-forming cell response to trinitrophenyl-nuclease equivalent to that provided by helper T cells from the spleens of nuclease-primed animals. Helper T cells from both anti-idiotype-treated and nuclease-treated animals were found to be antigen-specific and to be similarly susceptible to elimination by treatment with anti-idiotype plus complement. Therefore, treatment with both antigen and anti-idiotype appeared to prime similar populations of antigen-specific helper T cells, while having different effects on the induction of antibody. These findings are consistent with the network theory of receptor interactions in the immune response, and may provide a means for studying individual cell population...Continue Reading

References

May 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F L OwenA Nisonoff
Jul 1, 1978·European Journal of Immunology·M H JuliusA A Augustin
Nov 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·P A Cazenave
Nov 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·J UrbainC Collignon
Feb 1, 1976·European Journal of Immunology·H Cosenza
Dec 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·L Kluskens, H Köhler
Aug 25, 1971·Nature: New Biology·C CheersJ F Miller
Oct 1, 1973·European Journal of Immunology·M H JuliusL A Herzenberg
Oct 1, 1975·European Journal of Immunology·K Eichmann, K Rajewsky

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Citations

May 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·S K DattaR S Schwartz
May 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·G T NepomK E Hellström
Jan 1, 1982·The Journal of Experimental Medicine·G G MillerD H Sachs
Apr 1, 1982·The Journal of Experimental Medicine·A J InfanteC G Fathman
Nov 1, 1983·European Journal of Immunology·D MaleI Roitt
Apr 1, 1982·European Journal of Immunology·R Grützmann, G J Hämmerling

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