PMID: 9557987Apr 29, 1998Paper

Induction of immune-mediated hearing loss in SCID mice by injection of MRL/lpr mouse spleen cells

Hearing Research
H IwaiT Yamashita

Abstract

Induction of immune-mediated hearing loss in SCID mice by injection of MRL/lpr mouse spleen cells The MRL/lpr mouse, which has a mutation in the Fas gene encoding a cell-surface receptor for apoptosis, shows an accumulation of abnormal immunocompetent cells and SLE-like disease. It has recently been reported that this mouse also manifests sensorineural hearing loss (SHL) with cochlear pathology at 20 weeks of age. We examined the effects of injecting MRL/lpr spleen cells on the development of SHL in severe combined immunodeficient (SCID) mice, which originally develop neither SHL nor cochlear pathology. Immune-mediated SHL and cochlear pathology were, indeed, transferred to the SCID mice by the injection of spleen cells from the MRL/lpr mice. These findings suggest that cell-mediated immunity is involved in the development of SHL and cochlear pathology.

References

Sep 1, 1979·The Annals of Otology, Rhinology, and Laryngology·B F McCabe
Jan 1, 1991·Acta Oto-laryngologica·H S Li, E Borg
Sep 1, 1990·The Journal of Experimental Medicine·M A DuchosalF J Dixon
Apr 1, 1985·European Journal of Immunology·D EilatA Zlotnick
May 1, 1972·Annals of the Rheumatic Diseases·C J GoodwillR P Jones
Aug 1, 1971·The Laryngoscope·D T Cody, D A Sones
Feb 10, 1983·Nature·G C BosmaM J Bosma
Apr 1, 1980·Archives of Otolaryngology·I Brama, M Fainaru
Mar 1, 1993·Acta Oto-laryngologica·M J RuckensteinR V Harrison
May 1, 1996·Hearing Research·D R TruneC Mitchell
Aug 24, 1999·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·C BanotaiJ J Pestka

❮ Previous
Next ❯

Citations

Feb 13, 2003·Experimental Gerontology·Hiroshi IwaiSusumu Ikehara
Feb 24, 2004·Acta Oto-laryngologica·Hiroshi IwaiToshio Yamashita
Nov 18, 2000·Bone Marrow Transplantation·S LeeS Ikehara

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Auditory Perception

Auditory perception is the ability to receive and interpret information attained by the ears. Here is the latest research on factors and underlying mechanisms that influence auditory perception.