Induction of immunological tolerance using monoclonal antibodies: applications to organ transplantation and autoimmune disease

Comptes rendus biologies
Jean-François Bach

Abstract

Immunologic tolerance is a state of immune paralysis specific to a given antigen (the tolerogen) coexisting with the maintenance of normal immunocompetence towards other antigens. Anti-T cell monoclonal antibodies allow its induction in organ transplantation and autoimmune disease essentially through the stimulation of regulatory T cells. Very promising results obtained in animals have been recently confirmed in the human in recent-onset insulin-dependent diabetes mellitus with an anti-CD3 antibody (with long-term remission of the disease following a treatment of only six days).

References

Oct 10, 1995·Proceedings of the National Academy of Sciences of the United States of America·D C ParkerA A Rossini
Jan 4, 1994·Proceedings of the National Academy of Sciences of the United States of America·L ChatenoudJ F Bach
Feb 4, 2003·Nature Reviews. Immunology·Lucienne Chatenoud
Dec 16, 2003·Proceedings of the National Academy of Sciences of the United States of America·Marie-Alexandra AlyanakianJean-François Bach
Apr 20, 2005·The Journal of Experimental Medicine·Silvia GregoriMaria-Grazia Roncarolo
Jun 24, 2005·The New England Journal of Medicine·Bart KeymeulenLucienne Chatenoud
Jul 23, 2005·International Reviews of Immunology·Shimon Sakaguchi, Noriko Sakaguchi

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Citations

Apr 9, 2013·Cellular & Molecular Immunology·Haoyu SunWeihua Xiao
Jun 19, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A SiepertP Reinke
Feb 9, 2007·Journal of the American Society of Nephrology : JASN·Marina NorisGiuseppe Remuzzi

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