Induction of inducible nitric oxide synthase by lipopolysaccharide/interferon gamma and sepsis down-regulates 5-lipoxygenase metabolism in murine alveolar macrophages

Experimental Lung Research
Michael CoffeyMarc Peters-Golden

Abstract

Pretreatment with lipopolysaccharide (LPS) suppresses rat alveolar macrophage leukotriene synthesis in a nitric oxide (NO)-dependent mechanism. The authors examined the effect of NO on alveolar macrophage leukotriene synthesis following in vitro and in vivo models of sepsis. Treatment of alveolar macrophages from inducible NO synthase (iNOS) wild-type but not knock-out mice with LPS inhibited leukotriene synthesis. iNOS was induced early in alveolar macrophages from cecal ligation and puncture rats and mice compared to sham animals with associated reduced leukotriene synthesis. iNOS knock-out mice were protected from the decrease in alveolar macrophage 5-lipoxygenase metabolism. iNOS regulates alveolar macrophage 5-lipoxygenase metabolism following endotoxin exposure.

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Citations

Jan 16, 2007·Archivum Immunologiae Et Therapiae Experimentalis·Megan N BallingerBethany B Moore
Sep 12, 2009·Circulation Research·Volker Rudolph, Bruce A Freeman
Oct 4, 2013·Mediators of Inflammation·Ewa Pniewska, Rafal Pawliczak
Jun 25, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Min HwangboYoung Woo Kim
Nov 30, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Seong Kyu ParkSang Chan Kim
Nov 13, 2007·Experimental and Molecular Pathology·Li C ChenDebra L Laskin
Feb 10, 2009·Free Radical Biology & Medicine·Paul R S BakerBruce A Freeman
Jul 5, 2011·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·R Márquez-VelascoR Bojalil
Jan 7, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marc Peters-GoldenMichael J Coffey
Mar 1, 2006·Current Opinion in Allergy and Clinical Immunology

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