Induction of infertility by the Chlamydia trachomatis mouse pneumonitis biovar in strains of mice that differ in their response to the 60 kDa heat shock protein

Journal of Reproduction and Fertility
A KhamesipourLuis M de la Maza


To determine the role that the host response to the chlamydial 60 kDa heat shock protein (hsp) plays in the pathogenesis of infertility, C3H/HeN (H-2k) and C57BL/6 (H-2b) mice were inoculated in the left ovarian bursa with 1 x 10(5) inclusion forming units of the Chlamydia trachomatis mouse pneumonitis (MoPn) biovar, and in the right ovarian bursa with mock-infected HeLa-229 cell extracts. Control mice were inoculated with mock-infected HeLa-229 cell extracts. These two strains of mice were chosen because the C3H mice mount a strong immune response to the 60 kDa hsp, whereas the C57BL/6 mice respond only weakly. Vaginal cultures obtained after inoculation were positive for 4 weeks in both strains of mice. Histological sections showed a marked acute inflammatory infiltrate that permeated all the layers of the oviduct and lasted for approximately 2 weeks in both strains. By the third week, mononuclear inflammatory cells were also observed and from 4 weeks after inoculation, hydrosalpinx formation was observed, particularly in the C3H mice. An inclusion immunofluorescence assay detected antibodies specific for chlamydia in the serum and the vaginal washes of the C3H and C57BL/6 mice. Western blot analysis of the serum samples show...Continue Reading


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