PMID: 8938574Nov 1, 1996Paper

Induction of inflammatory cytokines in placental monocytes of gravidae infected with the human immunodeficiency virus type 1

Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research
J M ReubenW T Shearer

Abstract

Placental mononuclear cells (PMC) are susceptible to infection with the human immunodeficiency virus (HIV). PMC secreted tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta), and IL-6 among other factors, which, in turn, regulate HIV replication in latently infected cells. We assessed the induction of these cytokines in PMC from HIV-infected (HIV+) and uninfected (control) gravidae following exposure to lipopolysaccharide (LPS), HIV lysate (iHIV), recombinant HIV env (GP160) and HIV gag (gag55), and synthetic HIV p17 (HGP30) antigens. In comparison to control PMC, HIV+ PMC constitutively secreted higher levels of IL-1beta and IL-6 and were refractory to stimulation by iHIV, GP160, gag55, and HGP30. Control PMC IL-1 beta levels were boosted by LPS; gag55 and HGP30 augmented IL-6 but not IL-1 beta. Both groups exhibited low basal TNF-alpha production that was augmented by LPS. HIV+ PMC exhibited higher constitutive levels of IL-1 beta, IL-6, and TNF-alpha gene transcription than control PMC. These levels could be further augmented by LPS, yet the incremental levels were lower than those obtained from PMC of uninfected women. The high basal constitutive secretion of cytokines by HIV+ PMC and their refractoriness to activat...Continue Reading

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Citations

Jun 19, 2013·Immunological Reviews·Christina C ChangSharon R Lewin
Sep 16, 2016·Frontiers in Immunology·Bahaa Abu-RayaArnaud Marchant
Jun 20, 2017·Nature Reviews. Immunology·Gil MorAyesha B Alvero

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