Induction of insulin-like growth factor-I by interleukin-17F in bronchial epithelial cells

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
Mio KawaguchiNobuyuki Hizawa

Abstract

Increased expression of IL-17F has been noted in the airway of asthmatic patients, but its role in asthma has not been fully elucidated. Insulin-like growth FACTOR-I (IGF-I) is known to be involved in airway remodelling and inflammation, while its regulatory mechanisms remain to be defined. To further clarify the biological function of IL-17F, we investigated whether IL-17F is able to regulate the expression of IGF-I in bronchial epithelial cells. Bronchial epithelial cells were stimulated with IL-17F in the presence or absence of T-helper type 2 cytokines. Various kinase inhibitors were added to the culture to identify the key signalling events leading to the expression of IGF-I, in conjunction with the use of short interfering RNAs (siRNAs) targeting mitogen- and stress-activated protein kinase (MSK) 1, p90 ribosomal S6 kinase (p90RSK), and cyclic AMP response element-binding protein (CREB). IL-17F significantly induced IGF-I gene and protein expression, and co-stimulation with IL-4 and IL-13 augmented its production. MAP kinase kinase (MEK) inhibitors and the Raf1 kinase inhibitor significantly inhibited IGF-I production, and the combination of PD98059 and Raf1 kinase inhibitor showed further inhibition. Overexpression of Ra...Continue Reading

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Citations

Oct 21, 2011·Journal of Allergy·Kyoko NozatoNobuyuki Hizawa
Dec 6, 2012·Biochemical and Biophysical Research Communications·Chang Hoon BaeYong-Dae Kim
May 16, 2014·Journal of Immunology Research·Kyoko OtaNobuyuki Hizawa
Mar 27, 2019·Journal of Gastrointestinal Cancer·Sebastian MafeldJeremy French
Dec 14, 2011·Current Opinion in Allergy and Clinical Immunology·Vamsi P Guntur, Carol R Reinero
Jul 19, 2018·BioMed Research International·Zheng WangXiaoju Zhang
May 6, 2017·Immunity, Inflammation and Disease·Masayuki NakajimaNobuyuki Hizawa
Oct 28, 2019·Frontiers in Pharmacology·Hui Min YapMohd Roslan Sulaiman
Dec 15, 2020·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Yueh-Ying HanJuan C Celedón

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