Induction of interleukin-10 and suppressor of cytokine signalling-3 gene expression following peptide immunotherapy

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
M TarziMark Larché

Abstract

Allergen-derived (T cell epitope) peptides may be safer for immunotherapy than native allergen, as they do not cross-link immunoglobulin (Ig)E. However, HLA polymorphism results in multiple potential epitopes. Synthetic peptides of phospholipase (PL) A(2) were selected for a peptide vaccine, on the basis of binding affinity for commonly expressed HLA-DR molecules. To evaluate treatment with an HLA-DR-based PLA(2) peptide vaccine in subjects with mild honeybee allergy in an open, controlled study. Twelve volunteers with allergy to bee venom received nine intradermal injections of PLA(2) peptides, with six untreated subjects serving as controls. Outcome was assessed by the size of the late-phase cutaneous reaction to allergen, peripheral blood mononuclear cell (PBMC) proliferation, cytokine release, and expression of genes associated with immune regulation. Subjects receiving peptides showed a decrease in the magnitude of the late-phase cutaneous reaction to bee venom compared with controls (P=0.03). The proliferation of venom-stimulated PBMCs decreased in treated subjects compared with controls (P=0.01). Peptide treatment reduced the production of IL-13 by PLA(2)-stimulated PBMCs (P<0.01) and IFN-gamma (P<0.01), and increased th...Continue Reading

References

Jul 27, 1978·The New England Journal of Medicine·K J HuntL M Lichtenstein
Jan 1, 1981·International Archives of Allergy and Applied Immunology·A W van Toorenenbergen, R C Aalberse
Dec 1, 1996·American Journal of Respiratory and Critical Care Medicine·P S NormanC F Nicodemus
May 9, 1998·The Journal of Allergy and Clinical Immunology·G V MarcotteD M Essayan
Jul 3, 1998·The Journal of Clinical Investigation·C A AkdisK Blaser
Nov 5, 1998·The Journal of Allergy and Clinical Immunology·J PèneJ Bousquet
Mar 30, 1999·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·C A Akdis, K Blaser
Aug 12, 1999·The New England Journal of Medicine·S R DurhamK T Nouri-Aria
Oct 28, 1999·Allergy·M AbramsonJ Weiner
Dec 22, 1999·Clinical Immunology : the Official Journal of the Clinical Immunology Society·P MaguireD T Umetsu
Mar 8, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·C TexierB Maillère
Jul 6, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·D L DoolanA Sette
Mar 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Charles E EgwuaguIgal Gery
Jul 3, 2002·Nature Reviews. Immunology·Warren S Alexander
Jan 11, 2003·Science·Shohei HoriShimon Sakaguchi
Mar 4, 2003·Nature Immunology·Jason D FontenotAlexander Y Rudensky
Apr 22, 2003·The Journal of Allergy and Clinical Immunology·Jean-Marc FellrathFrançois Spertini
Jul 2, 2003·Expert Opinion on Biological Therapy·Michael Tarzi, Mark Larché
Jul 9, 2003·Nature Medicine·Yoh-ichi SekiMasato Kubo
Nov 12, 2003·The Journal of Allergy and Clinical Immunology·Petra A WachholzStephen R Durham

❮ Previous
Next ❯

Citations

Mar 20, 2012·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Young Ho LeeGwan Gyu Song
Oct 23, 2008·Current Allergy and Asthma Reports·Noel Rodríguez-PérezJay M Portnoy
Jan 15, 2013·Current Allergy and Asthma Reports·Linda CoxMark Larche
Jun 7, 2013·Current Allergy and Asthma Reports·Melina MakatsoriMoises A Calderon
Feb 19, 2010·Mucosal Immunology·A RayP Ray
Sep 26, 2006·Nature Reviews. Immunology·Mark LarchéRudolf Valenta
Nov 13, 2008·The Journal of Experimental Medicine·Flurina MeilerMübeccel Akdis
Nov 4, 2008·Current Opinion in Allergy and Clinical Immunology·Kathryn E Hulse, Judith A Woodfolk
Jun 10, 2009·The American Journal of Chinese Medicine·Sang Mi HanSok Cheon Pak
Sep 8, 2010·The American Journal of Chinese Medicine·Soo-Jung KimSok Cheon Pak
Mar 3, 2010·Annual Review of Immunology·Rudolf ValentaSusanne Vrtala
Jun 15, 2007·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Mark Larché
Jan 1, 2011·Clinical and Translational Allergy·Karen J MackenzieJürgen Schwarze
Jun 4, 2013·Clinical and Translational Allergy·Céline PellatonFrançois Spertini
Sep 10, 2010·Environmental Health Perspectives·Gillian S BackusSteven R Kleeberger
Mar 19, 2014·Cell Biochemistry and Biophysics·Guo TianDian Zhou
Feb 12, 2014·Proceedings of the National Academy of Sciences of the United States of America·Karen J MackenzieStephen M Anderton
Oct 12, 2014·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Y H LeeG G Song
May 28, 2015·Expert Review of Vaccines·Alessandra SandriniRobyn E O'Hehir
May 15, 2008·Expert Opinion on Biological Therapy·Mübeccel Akdis
Apr 7, 2009·Expert Opinion on Biological Therapy·Motohiko SuzukiWeiping Min
Jan 16, 2016·Current Allergy and Asthma Reports·Robyn E O'HehirJennifer M Rolland
Oct 25, 2011·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Cevdet OzdemirCezmi A Akdis
May 3, 2011·Immunology and Allergy Clinics of North America·Ozge U SoyerCezmi A Akdis
Mar 15, 2016·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Young Ho LeeGwan Gyu Song
Feb 24, 2016·Expert Review of Clinical Pharmacology·Cristoforo IncorvaiaErminia Ridolo
Jan 29, 2008·Trends in Biotechnology·Prem L Bhalla, Mohan B Singh
Apr 10, 2007·The Journal of Allergy and Clinical Immunology·Mark Larché
May 17, 2006·Immunology and Allergy Clinics of North America·Mark Larché
May 8, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C OzdemirC A Akdis
Sep 12, 2007·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C BussmannN Novak
Oct 4, 2006·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A AslamG Ogg
Jun 6, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·E A L BatemanG S Ogg
Feb 15, 2007·Allergy·M Larché
Jun 6, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M Larché
Dec 2, 2008·Clinical and Experimental Immunology·S L ThrowerM Peakman
Mar 27, 2009·Veterinary Dermatology·Christine Loewenstein, Ralf S Mueller

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.