Induction of interstitial pneumonia in autoimmune mice by intratracheal administration of superantigen staphylococcal enterotoxin B

Cellular Immunology
T ShinboriM Ando

Abstract

The pathogenesis of lung complications in autoimmune disease remains unclear. To examine whether superantigens participate in the development of interstitial pneumonia in autoimmune disease, we instilled the bacterial superantigen staphylococcal enterotoxin B (SEB) into the tracheas of autoimmune and nonautoimmune mice. The intratracheal administration of SEB resulted in the induction of interstitial pneumonia manifested by infiltration of mononuclear cells into the alveolar septal walls and into the periarterial space and an increase in pulmonary interstitial collagen fibers in the autoimmune mouse strains. In the nonautoimmune strains, AKR, but not BALB/c and B10BR, mice also developed interstitial pneumonia after the intratracheal administration of SEB, although the degree of severity was milder than that induced in three autoimmune mouse strains. Although the intratracheal administration of another bacterial superantigen staphylococcal enterotoxin A also induced interstitial pneumonia, protein A which is a staphylococcal product but not a superantigen induced no remarkable change in lungs of MRL-+/+ mice. Immunohistologic studies revealed that not only SEB-reactive Vbeta8+ T cells, but also SEB-nonreactive Vbeta6+ T cells i...Continue Reading

Citations

Nov 1, 2011·Seminars in Immunopathology·Dane Parker, Alice Prince
May 25, 2002·Allergy·C BachertP van Cauwenberge
Jul 10, 2003·Toxicologic Pathology·Vladimir SavranskyKonstantin Fegeding
Mar 23, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sarah J C WhitfieldAlun J Carter
Jul 17, 2019·BioMed Research International·Qinghua ZhangJunling Yang
Mar 1, 2008·Clinical and Experimental Otorhinolaryngology·Seong-Ki AhnDong-Gu Hur

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