PMID: 9544706Apr 17, 1998Paper

Induction of labor with intravaginal administration of misoprostol

International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics
R RodriguesM Meirinho

Abstract

The purpose of this study was to evaluate the efficacy and safety of intravaginal misoprostol for labor induction. 110 singleton term pregnancies with or without rupture of membranes were enrolled. Fractionated doses of misoprostol were applied (50-100 microg), every 6 h until a maximum of three doses or beginning of labor. The average interval (+/- S.D.) from vaginal application to the beginning of active labor and to delivery were, respectively, 9.5 +/- 5.7 h and 14.8 +/- 9.5 h. Failed labor induction was observed in two cases (2%). Cesarean section rate was 14%. The incidence of tachysystole was 18% and hypersystole 4%, but these situations were associated with abnormal fetal heart rate pattern (hyperstimulation) in only 3%. No maternal side effects and neonatal adverse effects were noted. Intravaginal misoprostol administration with low doses is an effective and safe method for labor induction in term pregnancies, with or without rupture of membranes.

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Citations

Jan 30, 2002·Obstetrics and Gynecology·Kelly BlanchardCaitlin Shannon
Dec 8, 2000·Journal of Obstetric, Gynecologic, and Neonatal Nursing : JOGNN·C Wilson
Sep 16, 1999·American Journal of Obstetrics and Gynecology·F NunesM Meirinho
Feb 18, 2006·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·H U Ezegwui

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