PMID: 6406637May 1, 1983Paper

Induction of lambda 1-immunoglobulin is determined by a regulatory gene (r lambda 1) linked (or identical) to the structural (c lambda 1) gene

The Journal of Experimental Medicine
R EpsteinM Cohn

Abstract

The cis-acting gene regulating specifically the inducibility of lambda 1-bearing B cells has been mapped within 2.9 cM of the structural gene. If the lambda 1lo-phenotype is due to the gly leads to val interchange in C lambda 1, then an argument can be made that (a) the lambda 1lo-phenotype is due to inefficient induction of lambda 1lo-bearing B cells and (b) B cell triggering is dependent upon a conformational change in the Ig receptor upon interaction with antigen. If the lambda 1lo-phenotype is due to a regulatory sequence linked to the structural C lambda 1-gene, then it must control the expression of the lambda 1-locus during development into adulthood, e.g., by an effect on methylation.

References

Nov 1, 1978·The Journal of Experimental Medicine·W GeckelerM Cohn
Nov 1, 1978·The Journal of Experimental Medicine·T Cotner, H N Eisen
Aug 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·G M WahlG R Stark
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Aug 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·E SelsingU Storb

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Citations

Jan 1, 1987·Immunogenetics·P D'EustachioD D Chaplin
Jan 1, 1986·Immunogenetics·R EpsteinM Cohn
Nov 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·P D'EustachioB A Cunningham
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·P SanchezP A Cazenave
Feb 1, 1984·The Journal of Experimental Medicine·S I NishikawaY Katsura
Sep 1, 1984·The Journal of Experimental Medicine·P D'Eustachio
Nov 1, 1985·The Journal of Experimental Medicine·B G Froscher, N R Klinman
Sep 1, 1989·The Journal of Experimental Medicine·J C Cambier, K R Lehmann
Jun 1, 1991·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·S L ZebedeeW C Raschke
Aug 1, 1986·Journal of Immunogenetics·D ZhouG A Gutman
Feb 12, 2008·Current Protocols in Molecular Biology·K LechN Irwin
Aug 7, 2007·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·David LöfAlex Evilevitch
Jul 1, 1997·Photochemistry and Photobiology·H Yoshida, J D Regan
Jan 1, 1988·Critical Reviews in Microbiology·J Maniloff
Mar 10, 2017·International Journal of Food Sciences and Nutrition·Mei YangJunrui Wu
Oct 31, 2012·Evolution; International Journal of Organic Evolution·Romain GalletIng-Nang Wang

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