Oct 25, 1976

Induction of lipogenesis during differentiation in a "preadipocyte" cell line

The Journal of Biological Chemistry
J C MackallM D Lane


3T3-L1 fibroblasts differentiate in culture into cells having adipocyte character. This transition is accompanied by a 40- to 50-fold rise in the incorporation of [14C]acetate into triglyceride. The increase in lipogenic rate is exactly parallel to a coordinate rise in the activities of the key enzymes of the fatty acid biosynthetic pathway (ATP-citrate lyase, acetyl-CoA carboxylase, and fatty acid synthetase). Immunological studies indicate that the elevated acetyl-CoA carboxylase activity is the product of an increased cellular enzyme level.

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Mentioned in this Paper

Fat Pad
Cell Differentiation Process
Fatty Acid Synthases
Acetyl-CoA Carboxylase
Cell Aggregation
ATP Citrate (pro-S)-Lyase
Acetic Acids

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