Induction of long-term memory CD8(+) T cells for recall of viral clearing responses against influenza virus

Journal of Virology
Georgia DeliyannisLorena E Brown

Abstract

Induction of cytotoxic T-cell-mediated virus-clearing responses by influenza virus T cell determinant-containing peptide immunogens was examined. The most potent synthetic immunogens for eliciting pulmonary viral-clearing responses contained peptides representing determinants for CD4 and CD8 T cells (TH and CTL peptides, respectively) together with two or four palmitic acid (Pal) groups. Inoculated in adjuvant, these Pal2- or Pal4-CTL-TH lipopeptides and the nonlipidated CTL peptide induced equivalent levels of cytolytic activity in the primary effector phase of the response. The ability to recall lytic responses, however, diminished much more rapidly in CTL peptide-primed than in lipopeptide-primed mice. By 15 months postpriming, the recalled lytic activity in lipopeptide-inoculated mice remained potent, but the response induced by the CTL peptide was weak. Enumeration of specific gamma interferon-secreting CD8 T cells revealed that a greater number of these T cells had entered or remained in the memory pool in lipopeptide-primed mice, arguing for a quantitative rather than qualitative enhancement of the response on recall. Addition of either the lipid or the TH peptide to the CTL peptide was not sufficient to provide these lo...Continue Reading

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Citations

Aug 6, 2003·Current Opinion in Immunology·Alessandro Sette, John Fikes
Mar 25, 2009·Immunology and Cell Biology·Lorena E Brown, Anne Kelso
Feb 24, 2010·Immunology and Cell Biology·David PejoskiDavid C Jackson
Jan 22, 2003·Immunology and Cell Biology·Brendon Y ChuaDavid C Jackson
Apr 7, 2004·The Journal of Experimental Medicine·Rika DraenertPhilip J R Goulder
Mar 8, 2005·Immunology and Cell Biology·Megan T SandersMartin J Pearse
Nov 22, 2012·Viruses·Carolien E van de SandtGuus F Rimmelzwaan
Oct 19, 2004·Proceedings of the National Academy of Sciences of the United States of America·David C JacksonLorena E Brown
Mar 3, 2011·Journal of Internal Medicine·K K McKinstryS L Swain
Aug 14, 2013·Clinical and Experimental Immunology·Gail D SckiselWilliam J Murphy
Jun 19, 2004·Cytotherapy·Gt BelzDc Jackson
Oct 14, 2005·Expert Review of Vaccines·Adriana BazAnne Kelso
Jun 6, 2014·Reproductive Sciences·Renju S RajMark Phillippe
Jan 26, 2018·Viral Immunology·Brendon Y ChuaDavid C Jackson
Jun 14, 2003·Journal of Peptide Science : an Official Publication of the European Peptide Society·Anthony W PurcellDavid C Jackson
Mar 3, 2007·Cancer Gene Therapy·A MurphyM H Kershaw
Jan 26, 2006·European Journal of Immunology·Georgia DeliyannisLorena E Brown
Dec 20, 2005·International Immunology·Bock LimAndrew M Lew
Jul 15, 2005·Journal of Medical Microbiology·Kouichirou ShinKimiyasu Shiraki
Jul 14, 2010·Expert Review of Vaccines·Claus Lundegaard
Jul 12, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Brendon Y ChuaDavid C Jackson

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