Induction of long-term potentiation and long-term depression is cell-type specific in the spinal cord

Pain
Hee Young KimJin Mo Chung

Abstract

The underlying mechanism of chronic pain is believed to be changes in excitability in spinal dorsal horn (DH) neurons that respond abnormally to peripheral input. Increased excitability in pain transmission neurons, and depression of inhibitory neurons, are widely recognized in the spinal cord of animal models of chronic pain. The possible occurrence of 2 parallel but opposing forms of synaptic plasticity, long-term potentiation (LTP) and long-term depression (LTD) was tested in 2 types of identified DH neurons using whole-cell patch-clamp recordings in mouse spinal cord slices. The test stimulus was applied to the sensory fibers to evoke excitatory postsynaptic currents in identified spinothalamic tract neurons (STTn) and GABAergic neurons (GABAn). Afferent conditioning stimulation (ACS) applied to primary afferent fibers with various stimulation parameters induced LTP in STTn but LTD in GABAn, regardless of stimulation parameters. These opposite responses were further confirmed by simultaneous dual patch-clamp recordings of STTn and GABAn from a single spinal cord slice. Both the LTP in STTn and the LTD in GABAn were blocked by an NMDA receptor antagonist, AP5, or an intracellular Ca chelator, BAPTA. Both the pattern and magn...Continue Reading

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Citations

Nov 23, 2017·Neuromodulation : Journal of the International Neuromodulation Society·Michael BehringerJoachim Mester
Jul 1, 2020·Frontiers in Neural Circuits·Erika K HardingRobert P Bonin
Dec 15, 2020·Biotechnology and Applied Biochemistry·Menglan Wang, Baskaran Thyagarajan
Jan 17, 2021·Biology of Sex Differences·Klaudia Pawlina-TyszkoMonika Bugno-Poniewierska
Apr 20, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Sajad FakhriMasoumeh Jorjani
Mar 25, 2021·European Journal of Pain : EJP·Charles QuesadaLuis Garcia-Larrea
Oct 22, 2021·Diabetic Medicine : a Journal of the British Diabetic Association·Di YePeter D Drummond

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Methods Mentioned

BETA
imaging technique

Software Mentioned

pCLAMP
NIH Image J

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