PMID: 8595671Feb 1, 1996Paper

Induction of longevity by cytoplasmic transfer of a linear plasmid in Podospora anserina

Current Genetics
J Hermanns, H D Osiewacz

Abstract

In Podospora anserina the longevity inducing linear plasmid pAL2-1 was transferred from the extrachromosomal long-lived mutant AL2 to the short-lived wild-type strain A. The resulting strain, AL2-IV, exhibited the long-lived phenotype. In the short-lived progeny of crosses between this strain and wild-type strain A, the plasmid was absent. In contrast, all long-lived progeny contained both the autonomous plasmid as well as copies of it integrated in the mitochondrial DNA (mtDNA). Molecular analysis revealed that the integrated plasmid copies most likely resulted from a de novo integration of the autonomous element and the generation of AT-linker sequences at the integration site. We conclude that once the plasmid is present in mitochondria of a particular genetic background, it is able to integrate into the mtDNA and to induce longevity.

References

Mar 27, 1979·Molecular & General Genetics : MGG·D J CummingsC Grandchamp
Jul 4, 1978·Molecular & General Genetics : MGG·U StahlK Esser
Dec 1, 1992·Journal of Molecular Evolution·F KempkenH D Osiewacz
May 1, 1992·Current Genetics·A J GriffithsC Myers
Oct 22, 1985·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·R NusseL van't Veer
Mar 1, 1995·Current Genetics·J HermannsH D Osiewacz
Jul 22, 1995·Molecular & General Genetics : MGG·F Kempken
Mar 10, 1995·Molecular & General Genetics : MGG·J HermannsH D Osiewacz
May 10, 1994·Molecular & General Genetics : MGG·J HermannsH D Osiewacz
Nov 11, 1993·Nature·C H SellemL Belcour
Feb 1, 1993·Molecular & General Genetics : MGG·X Yang, A J Griffiths

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Citations

Mar 1, 2002·Mechanisms of Ageing and Development·Heinz D Osiewacz
May 28, 2014·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Radek SzklarczykHeinz D Osiewacz
May 28, 2014·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Anne D van DiepeningenAlfons J M Debets
Jun 18, 2002·Ageing Research Reviews·Heinz D Osiewacz

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