PMID: 7543590Sep 1, 1995Paper

Induction of macrophage procoagulant activity by murine hepatitis virus strain 3: role of tyrosine phosphorylation

Journal of Virology
A P DackiwOri Rotstein

Abstract

The induction of a unique macrophage procoagulant molecule by murine hepatitis virus strain 3 correlates with the severity of viral hepatitis. The role of tyrosine phosphorylation in the signalling pathway leading to procoagulant expression was studied. Murine hepatitis virus strain 3 initiated a rapid increase in phosphotyrosine accumulation. Tyrosine kinase inhibition precluded this increase and abrogated expression of the virus-induced procoagulant mouse fibrinogen-like protein (musfiblp) gene. These findings suggest that manipulation of this signalling pathway in vivo might represent a novel approach to treating this disease.

References

Dec 1, 1992·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·J B BolenA Y Tsygankov
Nov 1, 1992·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·A Levitzki
Jan 1, 1983·Methods in Enzymology·J A CooperT Hunter
Apr 1, 1993·Trends in Biochemical Sciences·E Nishida, Y Gotoh

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