Induction of macrophage procoagulant by products of activated lymphocytes

Haemostasis
C L Geczy

Abstract

The induction of macrophage procoagulant activity by specific antigens is a close in vitro correlate of delayed-type hypersensitivity (DTH) reactions and provides a quantitative and sensitive measure of cell-mediated immune responses. The reaction is mediated by lymphokines from activated T lymphocytes and is potentiated by bacterial lipopolysaccharide. Lymphokines directly activated procoagulant activity on some murine and human macrophage tumor cell line cells although others required the collaboration of T lymphocytes, in the presence of lymphokine, to express activity. Macrophages in different stages of differentiation may vary, therefore, in their response to lymphokines. Pharmacological agents which regulate DTH reactions also mediated either the ability of lymphocytes to produce macrophage procoagulant inducing factor or the response of macrophages to the factors. Histamine and an anticoagulant found on stimulated T lymphocytes may be important regulatory mediators of macrophage procoagulant activity in vivo.

Citations

Mar 1, 1989·Biulleten' eksperimental'noĭ biologii i meditsiny·D M ZubairovG B Evranova
Jan 1, 1991·Comparative Biochemistry and Physiology. A, Comparative Physiology·A M FreyriaR Eloy
Jul 17, 1999·Atherosclerosis·E TremoliS Colli
Jul 17, 2008·Journal of Thrombosis and Haemostasis : JTH·A GonsalvesD S Allan
Aug 15, 1989·Archives of Biochemistry and Biophysics·U LindahlR Seljelid
Apr 15, 1986·International Journal of Cancer. Journal International Du Cancer·N SemeraroF Carpagnano

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.