Induction of macrophagic prostaglandin E2 synthesis by glioma cells

Journal of Neurosurgery
Yoshiteru NakanoUki Yamashita

Abstract

It has been reported that glioma cells produce prostaglandin (PG)E2, which promotes the growth of tumor cells and possesses immunosuppressive activity, and that cyclooxygenase (COX) inhibitors impede tumor growth and infiltration. Macrophages in tumor-bearing hosts are activated to produce PGE2, which induces an immunosuppressive state. Note, however, that the precise mechanism by which PGE2 induces an immunosuppressive state is still unclear. In this study, the authors investigated the mechanism of PGE2 production in glioma-bearing hosts. The human and murine glioma cells that were studied did not produce a significant amount of PGE2. However, the coculture of human peripheral blood mononuclear cells or murine peritoneal macrophages with glioma cells or conditioned glioma medium led to the production of a large amount of PGE2. In contrast, production of tumor necrosis factor and interleukin (IL)-12p70 by macrophages and cytotoxic T lymphocyte induction were suppressed by culturing with conditioned glioma medium; this suppression was abrogated by the addition of the COX inhibitor indomethacin. The macrophagic expression of COX-2, and particularly the expression of microsomal PGE synthase (mPGES)-1, a terminal enzyme of the arac...Continue Reading

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Citations

Jun 16, 2007·Cancer Immunology, Immunotherapy : CII·Diego O CrociO Graciela Scharovsky
Apr 7, 2009·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Simo MattilaFrej Stenbäck
Apr 13, 2010·Clinical Biochemistry·Rafael De ArmasYves Denizot
Jan 10, 2008·Expert Review of Anticancer Therapy·Adam M SonabendMaciej S Lesniak
Apr 15, 2011·Cell Biochemistry and Function·Luisa GenneroGian Piero Pescarmona
Dec 17, 2011·Journal of Neuro-oncology·Adam M SonabendRichard C E Anderson

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Methods Mentioned

BETA
density gradient centrifugation
flow cytometry
ELISA
reverse transcription PCR
PCR

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