PMID: 7544006Aug 15, 1995Paper

Induction of mammary epithelial hyperplasias and mammary tumors in transgenic mice expressing a murine mammary tumor virus/activated c-src fusion gene

Proceedings of the National Academy of Sciences of the United States of America
M A WebsterW J Muller

Abstract

Activation of the c-Src tyrosine kinase has been implicated as an important step in the induction of mammary tumors in both mice and humans. To directly assess the effect of mammary gland-specific expression of activated c-Src, we established transgenic mice that carry a constitutively activated form of c-src under transcriptional control of the murine mammary tumor virus long terminal repeat. Female mice derived from several independent transgenic lines lactate poorly as a consequence of an impairment in normal mammary epithelial development. In addition to this lactation defect, female mice frequently develop mammary epithelial hyperplasias, which occasionally progress to frank neoplasias. Taken together, these observations suggest that expression of activated c-Src in the mammary epithelium of transgenic mice is not sufficient for induction of mammary tumors.

References

Nov 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·C T GuyW J Muller
Jan 4, 1994·Proceedings of the National Academy of Sciences of the United States of America·D K LuttrellT M Gilmer

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Citations

Jun 8, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·P M SiegelW J Muller
Dec 1, 2006·Journal of Mammary Gland Biology and Neoplasia·Carol A PalmerJames L McManaman
May 13, 2005·Mutation Research·Qiang Shen, Powel H Brown
Oct 2, 1998·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·M L Labat
Sep 8, 2010·Oncogene·L HebbardR G Oshima
Jul 12, 2005·Oncogene·Ami S BhattMark M Moasser
Jun 2, 2011·Proceedings of the National Academy of Sciences of the United States of America·Richard MarcotteWilliam J Muller
Mar 28, 2002·Human Gene Therapy·Kara L NormanPatrick W K Lee
Jun 14, 2008·Development·Eran R AndrechekJoseph R Nevins
Jan 7, 2003·In Vitro Cellular & Developmental Biology. Animal·Michael J CampbellLaura J Esserman
Jul 14, 2010·Cancer Genetics and Cytogenetics·Andreas KleinPeter Duesberg
Nov 14, 2015·Biomolecular Concepts·Maximilian NiitLeda Raptis
Apr 26, 2013·The Journal of Pathology·Saadia A KarimValerie G Brunton
Sep 15, 2004·Critical Reviews in Oncology/hematology·Gilles Freiss, Françoise Vignon
May 23, 2015·Biochimica Et Biophysica Acta·Raghuveera Kumar Goel, Kiven Erique Lukong
May 16, 2008·Expert Opinion on Therapeutic Targets·Stephen Hiscox, Robert I Nicholson
Apr 29, 2014·Developmental Biology·Nadia OkolowskyPaul A Hamel
Jun 24, 2004·Toxicologic Pathology·Robert D CardiffJeffrey P Gregg
Mar 14, 2000·Oncogene·D L Dankort, W J Muller
Jan 1, 1996·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·J D BjorgeD J Fujita
Apr 14, 2018·Frontiers in Cell and Developmental Biology·Hidetoshi MoriAlexander D Borowsky

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