Induction of mammary gland hyperplasia and carcinomas in transgenic mice expressing human cyclin E.

Molecular and Cellular Biology
D M Bortner, M P Rosenberg

Abstract

Deregulated expression of several cell cycle regulatory genes has been demonstrated to be associated with cancer. In particular, a strong correlation has been established between inappropriate cyclin E expression and human breast cancer. To determine the ability of cyclin E to play a causative role in mammary tumorigenesis, regulatory sequences from the ovine beta-lactoglobulin gene were utilized to specifically target expression of human cyclin E to the mammary glands of pregnant and lactating mice. Lactating mammary glands of transgenic mice expressing cyclin E contained areas of hyperplasia, primarily papillary projections of hyperplastic cells, which were rarely observed in lactating glands of control mice. Over 10% of female cyclin E transgenic mice have developed mammary carcinomas, with latencies ranging from 8 to 13 months. Tumor analysis revealed the presence of transgene-specific cyclin E RNA and protein, as well as cyclin E- and cdk2-associated kinase activity, suggesting that cyclin E is likely a contributing component of tumorigenic progression in this model system.

References

Sep 1, 1992·Transgenic Research·M ShaniD R Hurwitz
Jan 1, 1992·Annual Review of Cell Biology·S I Reed
Jul 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·A L ArchibaldA J Clark
Jun 1, 1991·Molecular and Cellular Biology·T ChoiR Jaenisch
May 1, 1995·Molecular and Cellular Biology·M OhtsuboM Pagano
May 15, 1995·Genes & Development·C J Sherr, J M Roberts
Jul 1, 1995·Molecular and Cellular Biology·D Resnitzky, S I Reed
Nov 1, 1994·Trends in Biochemical Sciences·M J Solomon
Mar 9, 1995·Nature·D O Morgan
Dec 1, 1994·Current Opinion in Cell Biology·G F Draetta
Jan 1, 1994·Current Biology : CB·T JacksR A Weinberg
Nov 18, 1994·Cell·C J Sherr
Mar 1, 1994·Molecular and Cellular Biology·H MatsushimeJ Y Kato
Mar 1, 1994·Molecular and Cellular Biology·M Meyerson, E Harlow
Dec 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·V DulićG H Stein
Dec 24, 1993·Science·S van den Heuvel, E Harlow
Jan 18, 1994·Proceedings of the National Academy of Sciences of the United States of America·P W HindsR A Weinberg
Jun 1, 1993·Trends in Biochemical Sciences·J Pines
Mar 26, 1993·Science·M Ohtsubo, J M Roberts
Feb 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·K Keyomarsi, A B Pardee
Apr 1, 1993·The Journal of Cell Biology·M PaganoG Draetta
May 1, 1993·Genes & Development·V BaldinG Draetta

❮ Previous
Next ❯

Citations

Jun 28, 2001·Leukemia & Lymphoma·M Erlanson, G Landberg
Jan 6, 2006·Growth Factors·Elizabeth A Musgrove
Apr 2, 2015·International Journal of Molecular Sciences·Xun GuoRebecca S Hartley
Jul 5, 2005·Expert Opinion on Investigational Drugs·K R Webster
Aug 24, 2006·Neoplasia : an International Journal for Oncology Research·Mu-Shui DaiHua Lu
Jun 11, 2008·Cancer Letters·YingMeei TanCharles Spruck
Jul 29, 2010·Journal of Cellular Physiology·Siddik SarkarMahitosh Mandal
Sep 22, 2011·Wiley Interdisciplinary Reviews. RNA·Kotb Abdelmohsen, Myriam Gorospe
Jan 18, 2005·The Journal of Surgical Research·James T Wu, John G Kral
Mar 4, 2003·Nature Reviews. Cancer·Davide Ruggero, Pier Paolo Pandolfi
Jul 27, 2005·Seminars in Cancer Biology·Kelly K Hunt, Khandan Keyomarsi
Dec 29, 2013·Biochemical and Biophysical Research Communications·Xiao ZhangRui Zhang
May 12, 2015·Current Biology : CB·Leonardo K TeixeiraSteven I Reed
Aug 16, 2001·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·H K KimN K Kim
Nov 7, 2002·Current Biology : CB·Alex C MinellaBruce E Clurman
Oct 7, 2008·Cell Division·Gaurisankar Sa, Tanya Das
Aug 26, 2004·Molecular Cell·Oronza A BotrugnoKristina Schoonjans
Jul 19, 2005·Cancer Cell·Keith R LoebJames M Roberts
Nov 8, 2014·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Pei-Hsin ChengH Sam Zhou
Mar 8, 2014·BioMed Research International·Patrizia BonelliFranco Maria Buonaguro
May 20, 1999·Annual Review of Pharmacology and Toxicology·D G Johnson, C L Walker
Oct 10, 2008·Annual Review of Pathology·Kathleen R Cho, Ie-Ming Shih
May 13, 2005·Mutation Research·Qiang Shen, Powel H Brown
Jun 8, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·P M SiegelW J Muller
May 18, 2005·Proceedings of the National Academy of Sciences of the United States of America·Eleanor Y M SumJane E Visvader
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Yan MaEthan Dmitrovsky
Feb 3, 2005·Proceedings of the National Academy of Sciences of the United States of America·Kristina SchoonjansJohan Auwerx
Feb 10, 2004·Proceedings of the National Academy of Sciences of the United States of America·Michael T TetzlaffStephen J Elledge
Apr 5, 2012·Proceedings of the National Academy of Sciences of the United States of America·Dai HoriuchiAndrei Goga
Jan 28, 2017·Nature Reviews. Cancer·Tobias Otto, Piotr Sicinski
Jul 22, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Aparna Mani, Edward P Gelmann
Jun 18, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Andrew Arnold, Alexandros Papanikolaou
Oct 29, 1997·Proceedings of the National Academy of Sciences of the United States of America·J LangenfeldE Dmitrovsky
Mar 16, 2006·British Journal of Cancer·F ErlandssonA Zetterberg
Sep 27, 2006·Journal of Cellular Physiology·Michelle Craig BartonKhandan Keyomarsi
Apr 20, 2005·Oncogene·Harry C Hwang, Bruce E Clurman
May 5, 2007·International Journal of Offender Therapy and Comparative Criminology·Michelle Inderbitzin
Jul 12, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jeong-Hyeon KoKwang Seok Ahn
Jan 30, 2015·Technology in Cancer Research & Treatment·Lanshan HuangGang Chen

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