Induction of manganese superoxide dismutase in BV-2 microglial cells

Neuroreport
K SugayaM McKinney

Abstract

The regulation of the manganese-dependent superoxide dismutase (Mn-SOD) was studied in immortalized microglial cells (line BV-2). BV-2 cells, activated with lipopolysaccharide (LPS), exhibited an increase in Mn-SOD-like immunoreactivity, that was associated with an accumulation of nitrite in the culture medium and an increase in immunoreactivity for the inducible type of nitric oxide synthase (i-NOS). The i-NOS inhibitor L-N6-(1-iminoethyl)-lysine (NIL, 600 microM) suppressed the nitrite accumulation and the increase in Mn-SOD-like immunoreactivity in activated cells without significant effect on the level of i-NOS-like immunoreactivity. The NO donor sodium nitroprusside dose-dependently increased Mn-SOD-like immunoreactivity in NIL-pretreated BV-2 cells. These results indicate that the induction of Mn-SOD in activated BV-2 cells is mediated in part by NO, or its metabolites.

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Citations

Oct 26, 2001·Free Radical Biology & Medicine·S C ChangC T Lin
Apr 24, 2012·Clinical and Experimental Pharmacology & Physiology·Yoko S KanekoToshiharu Nagatsu
May 16, 2002·Experimental Neurology·Chun-Jung Chen, Su-Lan Liao
Jul 17, 2007·Biochemical Pharmacology·Shinrye Lee, Kyoungho Suk
Oct 30, 2001·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·K Sugaya
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Jun 17, 2006·Biochimica Et Biophysica Acta·Jana MehlhaseTilman Grune
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Apr 25, 2000·Journal of Neuroscience Research·E A MaleckiJ R Connor

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