PMID: 9438910Jan 24, 1998Paper

Induction of MHC class II antigen expression on human HMC-1 mast cells

Journal of Dermatological Science
J GrabbeB M Henz

Abstract

Mast cells are not only the primary effector cells of immediate type immune reactions, but they have recently also been considered to contribute to the induction of an immune response. Data on the ability of the cells to express major histocompatibility complex (MHC) antigens and the mechanisms involved are however controversial or unclear. We have therefore studied the expression of MHCI and the induction of MHCII molecules on leukemic HMC-1 mast cells by immunohistochemistry. Cells were incubated for up to 72 h in the presence of IFN gamma, TNF alpha and IL-4, and immunohistochemical staining was done with monoclonal antibodies with specificity for HLA class I heavy chain, HLA-DQ (Tü22), HLA-DR (Tü36) and HLA-DQ, -R and -P (Tü35). All unstimulated mast cells expressed MHC class I, but almost no class II antigens. Incubation with IFN gamma caused a rapid, dose-dependent induction of MHC class II molecules, with Tü35 staining maximally one third of the cells within 24 h at the highest dose tested (100 IU/ml), with decline on extended culture. TNF alpha (2 ng/ml) was less effective but caused more persistent induction with time. IL-4 (200 ng/ml) had hardly any effects at all. Staining with Tü22 and Tü36 was always lower than wit...Continue Reading

References

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Citations

Dec 7, 2007·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Ewa Brzezińska-BłaszczykAnna H Misiak-Tłoczek
Mar 18, 2005·Annual Review of Immunology·Stephen J GalliMindy Tsai
Jan 14, 2012·Endocrine Reviews·Jia-Ming Xu, Guo-Ping Shi
Feb 13, 2001·Experimental Dermatology·B M HenzM Babina
Aug 26, 2015·The Journal of Cell Biology·Amanda Carroll-PortilloDiane S Lidke
Jun 5, 2007·Immunobiology·Erietta StelekatiSilvia Bulfone-Paus
Jan 12, 2012·Microbiology and Immunology·Edyta BąbolewskaEwa Brzezińska-Błaszczyk
Apr 19, 2013·European Journal of Immunology·Jolien SuurmondRené E M Toes
May 15, 2007·Immunological Reviews·Stephan C Bischoff, Sigrid Krämer
Sep 30, 2010·Yonsei Medical Journal·Sebastian ReuterChristian Taube

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