Induction of micronuclei and superoxide production in neuroblastoma and glioma cell lines exposed to weak 50 Hz magnetic fields

Journal of the Royal Society, Interface
Kavindra Kumar KesariJonne Naarala

Abstract

Extremely low-frequency (ELF) magnetic fields (MF) have been associated with adverse health effects in epidemiological studies. However, there is no known mechanism for biological effects of weak environmental MFs. Previous studies indicate MF effects on DNA integrity and reactive oxygen species, but such evidence is limited to MFs higher (greater than or equal to 100 µT) than those generally found in the environment. Effects of 10 and 30 µT fields were studied in SH-SY5Y and C6 cells exposed to 50-Hz MFs for 24 h. Based on earlier findings, menadione (MQ) was used as a cofactor. Responses to MF were observed in both cell lines, but the effects differed between the cell lines. Micronuclei were significantly increased in SH-SY5Y cells at 30 µT. This effect was largest at the highest MQ dose used. Increased cytosolic and mitochondrial superoxide levels were observed in C6 cells. The effects on superoxide levels were independent of MQ, enabling further mechanistic studies without co-exposure to MQ. The micronucleus and mitochondrial superoxide data were consistent with a conventional rising exposure-response relationship. For cytosolic superoxide, the effect size was unexpectedly large at 10 µT. The results indicate that the thres...Continue Reading

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Citations

Sep 21, 2016·International Journal of Radiation Biology·Jukka LuukkonenJonne Naarala
Mar 8, 2017·International Journal of Radiation Biology·Anne HöytöJonne Naarala
Feb 16, 2018·DNA and Cell Biology·Hamideh Mahmoudinasab, Mostafa Saadat
Feb 13, 2018·Metabolic Brain Disease·Jit ChatterjeeMohammed S Mustak
Oct 3, 2018·PLoS Biology·Lukas Landler, David A Keays
Jan 23, 2019·International Journal of Radiation Biology·Emanuele Calabrò, Salvatore Magazù
Sep 5, 2020·International Journal of Environmental Health Research·Shiwangi GuptaRajeev Singh
May 26, 2018·Proceedings. Biological Sciences·Jukka JuutilainenP J Hore
Dec 3, 2020·International Journal of Radiation Biology·Rohit GautamPaulraj Rajamani
Dec 22, 2020·Electromagnetic Biology and Medicine·María Antonia MartínezMaría Ángeles Trillo
Apr 4, 2021·International Journal of Molecular Sciences·Olga García-Minguillán, Ceferino Maestú
May 1, 2021·International Journal of Molecular Sciences·David Schuermann, Meike Mevissen

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